1.00247

Ácido cítrico

anhydrous fine-granular, EMPROVE^® ESSENTIAL, Ph. Eur., BP, ChP, JP, USP, FCC, E 330

• Sinônimo(s): 2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid
• Fórmula linear: HOC(COOH)(CH₂COOH)₂
• Número CAS: 77-92-9
• Peso molecular: 192.12
• Beilstein: 782061
• Número MDL: MFCD00011669
• Código UNSPSC: 12352106
• Número E: E330
• Número do índice EC: 201-069-1

Propriedades

• Agency: BP; ChP; JP; Ph. Eur.; USP
• Nível de qualidade: 500
• conformidade reg.: FCC
• pressão de vapor: <0.1 hPa ( 20 °C)
• linha de produto: EMPROVE^® ESSENTIAL
• Ensaio: 99.5-100.5% substance (anhydrous) basis (alkalimetric)
• forma: coarse powder
• potência: 3000 mg/kg LD₅₀, oral (Rat)
• Lim. expl.: 8 %, 65 °F
• pH: 1.7 (20 °C, 100 g/L in H₂O)
• pKa: (1) 3.13, (2) 4.76, (3) 6.4
• pb: 200 °C/1013 hPa (decomposition)
• pf: 153-159 °C (lit.)
• solubilidade: water: 1330 g/L at 20 °C
• densidade: 1.665 g/cm³ at 18 °C
• traços de cátion: Al: ≤0.2 ppm; As: ≤1 ppm; Hg: ≤1 ppm; Pb: ≤0.5 ppm; heavy metals (as Pb): ≤5 ppm
• aplicação(ões): liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• temperatura de armazenamento: 2-30°C
• cadeia de caracteres SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O
• InChI: 1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
• chave InChI: KRKNYBCHXYNGOX-UHFFFAOYSA-N

Descrição

Descrição geral

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicação

Citric acid is typically used as pH adjuster, buffer agent or as antioxidant in pharmaceutical formulations. Its application range spans across different formulation types, including semi-solid dosage forms, liquid dosage forms such as solutions and solid dosage forms such as effervescent tablets or granules.
Citric acid anhydrous powder Emprove^® Essential is citric acid present in its water-free, fine granulated form.

Informações legais

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable