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C75

Name: C75
Brand: SIGMA

≥98% (HPLC), fatty acid synthase (FAS) inhibitor of, powder

Synonym(s):

4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₂O₄

CAS Number:

218137-86-1

Molecular Weight:

254.32

UNSPSC Code:

41121801

PubChem Substance ID:

24892789

NACRES:

NA.77

MDL number:

MFCD03426157

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Pricing and availability is not currently available.

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Properties

Product Name

C75, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

CCCCCCCCC1OC(=O)C(=C)C1C(O)=O

InChI

1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)

InChI key

VCWLZDVWHQVAJU-UHFFFAOYSA-N

Description

Application

C75 has been used:

as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Biochem/physiol Actions

C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.

C75 helps to increase the cancer‐killing capability of ionizing radiation.

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This Item	SML0497	C2992	SML0567
Sigma-Aldrich C5490 C75	Sigma-Aldrich SML0497 BQCA	Sigma-Aldrich C2992 CFTR(inh)-172	Sigma-Aldrich SML0567 BRD4770
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 5 mg/mL, clear	solubility DMSO: 10 mg/mL (clear solution)	solubility DMSO: ≥10 mg/mL, H₂O: insoluble	solubility DMSO: 5 mg/mL, clear (warmed)
color white to beige	color white to beige	color yellow	color white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Differential in radiosensitizing potency of enantiomers of the fatty acid synthase inhibitor C75

Rae C, et al.

Chirality, 29(1), 10-13 (2017)

The formation of lipid droplets favors intracellular Mycobacterium leprae survival in SW-10, non-myelinating Schwann cells.

Song-Hyo Jin et al.

PLoS neglected tropical diseases, 11(6), e0005687-e0005687 (2017-06-22)

Leprosy is a chronic infectious disease that is caused by the obligate intracellular pathogen Mycobacterium leprae (M.leprae), which is the leading cause of all non-traumatic peripheral neuropathies worldwide. Although both myelinating and non-myelinating Schwann cells are infected by M.leprae in

Classical Activation of Macrophages Leads to Lipid Droplet Formation Without de novo Fatty Acid Synthesis.

Mauricio Rosas-Ballina et al.

Frontiers in immunology, 11, 131-131 (2020-03-07)

Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro-inflammatory activation of macrophages remains incompletely characterized. We show here

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Global Trade Item Number

SKU	GTIN
C5490-25MG	04061833269985
C5490-5MG	04061833502198

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