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Cefsulodin sodium salt hydrate

Name: Cefsulodin sodium salt hydrate
Brand: SIGMA

third-generation cephalosporin antibiotic

Synonym(s):

7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₉N₄NaO₈S₂ · xH₂O

CAS Number:

52152-93-9

Molecular Weight:

554.53 (anhydrous basis)

NACRES:

NA.85

PubChem Substance ID:

24278340

UNSPSC Code:

51284140

EC Number:

257-692-4

MDL number:

MFCD07793338

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Properties

Quality Level

200

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1

InChI

1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

InChI key

REACMANCWHKJSM-DWBVFMGKSA-M

Description

General description

Chemical structure: β-lactam

Application

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier[1].

Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Show Differences

1 of 1

This Item	C5020	C5793	C7912
Sigma-Aldrich C8145 Cefsulodin sodium salt hydrate	Sigma-Aldrich C5020 Cefazolin sodium salt	Sigma-Aldrich C5793 Ceftriaxone disodium salt hemi(heptahydrate)	Sigma-Aldrich C7912 Cefotaxime sodium salt
antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder or crystals	form powder	form powder or crystals	form powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes	mode of action cell wall synthesis \| interferes

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Unstable Escherichia coli L forms revisited: growth requires peptidoglycan synthesis.

Danièle Joseleau-Petit et al.

Journal of bacteriology, 189(18), 6512-6520 (2007-06-26)

Growing bacterial L forms are reputed to lack peptidoglycan, although cell division is normally inseparable from septal peptidoglycan synthesis. To explore which cell division functions L forms use, we established a protocol for quantitatively converting a culture of a wild-type

Detection of hemolysin variants of Shiga toxin-producing Escherichia coli by PCR and culture on vancomycin-cefixime-cefsulodin blood agar.

A Lehmacher et al.

Applied and environmental microbiology, 64(7), 2449-2453 (1998-07-02)

The presence of a hemolysin-encoding gene, elyA or hlyA, from Shiga toxin-producing Escherichia coli (STEC) was detected by PCR in each of 95 strains tested. PCR products of elyA from human STEC isolates of serovars frequently detected in Germany, such

Genotypic analyses of shiga toxin-producing Escherichia coli O157 and non-O157 recovered from feces of domestic animals on rural farms in Mexico.

Bianca A Amézquita-López et al.

PloS one, 7(12), e51565-e51565 (2012-12-20)

Shiga toxin-producing Escherichia coli (STEC) are zoonotic enteric pathogens associated with human gastroenteritis worldwide. Cattle and small ruminants are important animal reservoirs of STEC. The present study investigated animal reservoirs for STEC in small rural farms in the Culiacan Valley

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Global Trade Item Number

SKU	GTIN
C8145-250MG	04061833521861
C8145-100MG	04061838820433
C8145-1G	04061833521854

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