I0879

Inosin-5′-Triphosphat Trinatriumsalz

≥95%

• Synonym(e): ITP
• Empirische Formel (Hill-System): C₁₀H₁₂Na₃N₄O₁₄P₃
• CAS-Nummer: 35908-31-7
• Molekulargewicht: 574.11
• MDL-Nummer: MFCD00084678
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24895910
• NACRES: NA.51

Eigenschaften

• Assay: ≥95%
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: [Na].OC1C(O)C(OC1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n2cnc3C(=O)N=CNc23
• InChI: 1S/C10H15N4O14P3.Na.H/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20);;
• InChIKey: RIERCUPIZLBNFQ-UHFFFAOYSA-N
• Angaben zum Gen: human ... HRAS(3265)

Beschreibung

Anwendung

Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. ITP may be used as a substrate to study the specificity and kinetics of nucleoside-5′-triphosphatase and ATPase. ITP is also used to study activation of various ATPases and GTPases.

Inosine 5′-triphosphate trisodium salt has been used to investigate its influence on the chromosome aberration rate, the mitotic rate, sister-chromatid exchange (SCE) frequency, the proportion of first (X1), second (X2) and third (X3) division metaphases of human peripheral lymphocytes.[1]

Biochem./physiol. Wirkung

Inosine 5′-triphosphate (ITP) has the ability to support the initiation of effector system. It can prevent guanosine 5′-triphosphate (GTP) hydrolysis, that is catalysed by transducin (TD). ITP can proficiently induce secretion in permeabilized cells than GTP.[2] Instead of GTP, ITP can be used for the initiation and the elongation steps of reovirus transcription.[3] ITP can also replace GTP in the activation of G-protein.[2]

Angaben zur Herstellung

Prepared from Bacterial ATP

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable