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C2743
Cytochalasin B aus Drechslera dematioidea
Ready Made Solution, 10 mg/mL in DMSO
Synonym(e):
Phomin
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200 μL
€ 145,00
About This Item
Empirische Formel (Hill-System):
C29H37NO5
CAS-Nummer:
Molekulargewicht:
479.61
Beilstein:
1096207
MDL-Nummer:
UNSPSC-Code:
51102829
PubChem Substanz-ID:
NACRES:
NA.85
Empfohlene Produkte
Qualitätsniveau
Form
solution
Konzentration
10 mg/mL in DMSO
Wirkungsspektrum von Antibiotika
fungi
Wirkungsweise
cell membrane | interferes
Lagertemp.
−20°C
SMILES String
C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
InChIKey
GBOGMAARMMDZGR-TYHYBEHESA-N
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Verwandte Kategorien
Anwendung
Cytochalasin B from Drechslera dematioidea has been used:
- to block cytokinesis, to obtain binucleated cells[1]
- as a specific glucose transporter inhibitor[2]
- to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells[3]
Biochem./physiol. Wirkung
Gehört zu einer Gruppe von Stoffwechselprodukten aus Pilzen, die eine Vielzahl zellulärer Bewegungen stören. Geeignetes Hilfsmittel für die Charakterisierung von einigen der Polymerisierungseigenschaften von Aktin und in Studien zur Zytokinese. Sonde für die beiden Hexose-Transportsysteme in L6-Myoblasten der Ratte.
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.[7]
Sonstige Hinweise
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
Lagerklassenschlüssel
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 2
Flammpunkt (°F)
185.0 °F - closed cup - Solvent
Flammpunkt (°C)
85 °C - closed cup - Solvent
Persönliche Schutzausrüstung
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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What is the Department of Transportation shipping information for this product?
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Is Product C2743, Cytochalasin B, cell culture grade?
1 answer-
The product has been sterile filtered, but it has not been cell culture tested by Sigma.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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I have a solution of Product C2743, Cytochalasin B, in DMSO. Is the DMSO toxic to cultured cells?
1 answer-
At a low enough concentration, the DMSO should not hurt the cells. The final concentration of DMSO in the aqueous working medium typically should not exceed 0.1% because higher DMSO concentrations can adversely affect many cultured cells. Dilute the product in the appropriate aqueous medium to provide a physiologically acceptable final concentration.
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