D2629

6-(Dimethylamino)purin

≥98%

• Synonym(e): N⁶,N⁶-Dimethyladenin
• Empirische Formel (Hill-System): C₇H₉N₅
• CAS-Nummer: 938-55-6
• Molekulargewicht: 163.18
• Beilstein: 7634
• EG-Nummer: 213-344-3
• MDL-Nummer: MFCD00005573
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24893701
• NACRES: NA.51

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥98%
• Form: powder
• mp (Schmelzpunkt): 259-262 °C (lit.)
• Löslichkeit: water: 50 mg/mL, clear to hazy, colorless to light yellow
• Lagertemp.: −20°C
• SMILES String: CN(C)c1ncnc2[nH]cnc12
• InChI: 1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
• InChIKey: BVIAOQMSVZHOJM-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

6-(Dimethylamino)purine (6-DMAP) is a purine-based metabolite with two condensed heterocyclic rings and two methyl groups linked to the amino group of the purine unit of adenine.

Anwendung

6-(Dimethylamino)purine has been used:

• as a supplement in GR-1 aa medium (bovine medium) for parthenogenetic activation of bovine oocytes to study its potential for embryo development
• in the activation step during the production of nuclear transfer embryos
• as a supplement in HCR2aa medium to activate interspecies embryos derived from interspecies somatic cell nuclear transfer (iSCNT) technique

Biochem./physiol. Wirkung

6-(Dimethylamino)purine (6-DMAP) is a protein kinase and cyclin-dependent kinase inhibitor. It acts as a secondary metabolite and mediates RNA modification. 6-DMAP is a potent cytokinetic inhibitor and is used in parthenogenesis and meiosis studies. It is also used to promote pronuclei formation in mammalian oocytes. 6-DMAP is a dual fluorescence molecule according to femtosecond fluorescence up-conversion spectroscopy studies.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)