A7410

Amiloride hydrochloride hydrate

≥98% (HPLC), powder, T-type calcium channel blocker

• Synonym(e): N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
• Empirische Formel (Hill-System): C₆H₈ClN₇O · HCl · xH₂O
• CAS-Nummer: 2016-88-8
• Molekulargewicht: 266.09 (anhydrous basis)
• MDL-Nummer: MFCD03703482
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277817
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Amiloride hydrochloride hydrate, ≥98% (HPLC), powder
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow
• mp (Schmelzpunkt): 285-288 °C (dec.)
• Löslichkeit: H₂O: 50 mg/mL, clear, yellow-green
• Ersteller: Perrigo
• Lagertemp.: room temp
• SMILES String: O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
• InChI: 1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2
• InChIKey: WDZJJRLYFQNCQL-UHFFFAOYSA-N
• Angaben zum Gen: human ... ABP1(26) , ACCN1(40) , ACCN2(41) , PLAU(5328) , SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , TNF(7124) ; mouse ... Abp1(76507) , Accn1(11418) , Accn2(11419) , Plau(18792) , Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) , Slc9a1(20544) ; rat ... Abp1(65029) , Accn1(25364) , Accn2(79123) , Plau(25619) , Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782)

Beschreibung

Anwendung

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

Biochem./physiol. Wirkung

Selective T-type Ca²⁺ and epithelial sodium channel blocker

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Vorsicht

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Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges