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Biochem./physiol. Wirkung
Gemischter NMDA-Agonist-/Antagonist an der Polyaminstelle. Spielt eine Rolle bei der Zellproliferation und -differenzierung, hemmt die Neuronale Stickstoffmonoxid-Synthase (nNOS).
Gemischter NMDA-Glutamatrezeptor-Agonist/-Antagonist an der Polyaminstelle. In hohen Konzentrationen (1 mM) wurden neuroprotektive Wirkungen beobachtet, bei niedrigeren Konzentrationen tritt dagegen eine Neurotoxizität auf. Verstärkt die Agonistenwirkung an der für Strychnin unempfindlichen Glycin-Stelle. Spielt eine Rolle bei der Zellproliferation und -differenzierung, hemmt die Neuronale Stickstoffmonoxid-Synthase (nNOS).
Current cancer drug targets, 9(2), 118-130 (2009-03-12)
The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating cells attracted the interest of scientists during last decades, addressing PA depletion as a new
Mg-ATP binding: its modification by spermine, the relevance to cytosolic Mg2+ buffering, changes in the intracellular ionized Mg2+ concentration and the estimation of Mg2+ by 31P-NMR.
Cellular and molecular life sciences : CMLS, 67(1), 113-121 (2009-10-28)
Spermine is present in many organisms including animals, plants, some fungi, some archaea, and some bacteria. It is synthesized by spermine synthase, a highly specific aminopropyltransferase. This review describes spermine synthase structure, genetics, and function. Structural and biochemical studies reveal
American journal of physiology. Endocrinology and metabolism, 294(6), E995-1010 (2008-03-20)
Spermidine/spermine-N(1)-acetyltransferase (SSAT) regulates cellular polyamine content. Its acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. Since polyamines play critical roles in normal and neoplastic growth and in ion channel regulation, SSAT is a key enzyme
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
