Based on a density of 0.925 g/mL and a molecular weight of 145.25 g/mol, this neat liquid has an effective molarity of 6.4 M. A 1 M stock is prepared by diluting the 6.4 M stock using the relation C1V1 = C2V2. For example, dilute 156 µL of spermidine to 1 mL with water to obtain a 1 M solution.
Fortfahren mit
S2626
Spermidin
synthetic, ≥99% (GC), neuronal nitric oxide synthase (nNOS) inhibitor, solid or liquid (clear)
Synonym(e):
1,8-Diamino-4-azaoctan, N-(3-Aminopropyl)-1,4-diaminobutan
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 g | Warenkorb auf Verfügbarkeit prüfen | € 51,40 |
5 g | Warenkorb auf Verfügbarkeit prüfen | € 182,00 |
25 g | Warenkorb auf Verfügbarkeit prüfen | € 674,00 |
Über diesen Artikel
Lineare Formel:
NH2(CH2)3NH(CH2)4NH2
CAS-Nummer:
Molekulargewicht:
145.25
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-689-0
MDL number:
Beilstein/REAXYS Number:
1698591
Technischer Dienst
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Unterstützung erhaltenProduktname
Spermidin, ≥99% (GC)
biological source
synthetic
Quality Segment
assay
≥99% (GC)
form
solid or liquid (clear)
impurities
DNase, none detected, RNase, none detected, protease, none detected
refractive index
n20/D 1.479 (lit.)
mp
22-25 °C
solubility
water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
density
0.925 g/mL at 25 °C (lit.)
storage temp.
room temp
SMILES string
NCCCCNCCCN
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChI key
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Gene Information
rat ... Ppm1a(24666)
General description
The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.
Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.
Application
Spermidine has been used:
- in the preparation of 5x transcription buffer
- in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
- as a standard in the analytical study of rat brain polyamines (185)
Biochem/physiol Actions
Hemmt die neuronale Stickoxidsynthase (nNOS). Bindet und fällt DNA aus; kann zur Aufreinigung von DNA-Bindungsproteinen verwendet werden. Stimuliert die T4-Polynukleotidkinaseaktivität.
Hemmt die neuronale Stickoxidsynthase (nNOS). Bindet und fällt DNA aus; stimuliert die T4-Polynukleotidkinaseaktivität.
Other Notes
Store under inert gas. Air sensitive; strongly hygroscopic.
Disclaimer
Für eine sterile Lösung soll die Lösung steril-filtriert und nicht autoklaviert werden. Spermidin deaminiert mit der Zeit; Lösungen tiefgekühlt lagern. Regelmässig frische Lösungen zubereiten.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥99% (GC) | description BioReagent, Molecular Biology, suitable for cell culture, ≥98% | description analytical standard | description - |
| biological source synthetic | biological source - | biological source - | biological source - |
| assay ≥99% (GC) | assay ≥98% | assay ≥99.0% (GC), ≥97.5% (NT) | assay - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form solid or liquid (clear) | form solid or liquid | form - | form - |
| impurities RNase, none detected, DNase, none detected, protease, none detected | impurities - | impurities - | impurities - |
| storage temp. room temp | storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C |
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Lagerklasse
8A - Combustible corrosive hazardous materials
flash_point_f
233.6 °F - closed cup
flash_point_c
112 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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I purchased S2626 5g spermidine, and it came in liquid form. My question is: given this solution, how do I prepare a 1 M stock? I want to know the molarity of this liquid spermidine and the storage condition of this purchased product.
1 answer-
Helpful?
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We have purchased S2626 spermidine 5 g. It does not say anywhere what molar concentration or if it is actually dissolved in water. Could you please inform me about that. I received 5 g i aprox 4 ml, and as I can read, the solubility is 50 mg /ml. ???
1 answer-
This product is supplied as a neat or pure liquid with a density of 0.925 g/mL and a molecular weight of 145.25 g/mol. The minimum purity is 99%, thus the molarity will vary slightly from lot to lot. The molarity can range from 6.3 M ( 99%) to 6.4 M (100%). The lot-specific purity is reported on the Certificate of Analysis.
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Is the Molarity for all Spermidin batches the same ? Does the 6,4 M count also for xx-1G and xx-25G?
1 answer-
The molarity of this compound is the same for all pack sizes, but may vary slightly from lot to lot. The reported 6.4 M is assuming a 100% purity. The minimum purity specification is 99%.
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What is the molarity of Spermidine S2626-5G solution and what is the longterm storage condition?
1 answer-
This product is a neat or pure liquid. Based on a density of 0.925 g/mL and a molecular weight of 145.25, this material has an effective molarity of 6.4 M. It is recommended to store this solution as single-use aliquots at -20 ºC for no more than one month.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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Is this a spermidine solution or a neat liquid, and what is the concentration?
1 answer-
Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.
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