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Methyldopa

Name: Methyldopa
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Methyl-DOPA sesquihydrate, 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine, MK-351, Methyl-L-DOPA

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₃NO₄ · 1.5H₂O

CAS Number:

41372-08-1

Molecular Weight:

238.24

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329750434

MDL number:

MFCD00004186

Beilstein/REAXYS Number:

2417244

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Properties

grade

pharmaceutical primary standard

API family

methyldopa

manufacturer/tradename

USP

mp

≥300 °C

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1

InChI key

CJCSPKMFHVPWAR-JTQLQIEISA-N

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Application

Methyldopa USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	Y0001083	M1500000	BP240
USP 1426002 Methyldopa	Y0001083 Methyldopa for system suitability	M1500000 Methyldopa	BP240 Methyldopa
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename EDQM	manufacturer/tradename BP
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
format neat	format neat	format neat	format neat
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule
API family methyldopa	API family methyldopa	API family methyldopa	API family methyldopa
mp ≥300 °C	mp ≥300 °C	mp ≥300 °C	mp ≥300 °C

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Liquid chromatography-tandem mass spectrometry method for the determination of tranexamic acid in human plasma.

Qi Chang et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 805(2), 275-280 (2004-05-12)

A new method for the determination of tranexamic acid (TA) in human plasma using high performance liquid chromatography with tandem mass spectrometric detection was described. TA and the internal standard, methyldopa, was extracted from a 200 l plasma sample by

The hypotensive activity and side effects of methyldopa, clonidine, and guanfacine.

P A van Zwieten et al.

Hypertension (Dallas, Tex. : 1979), 6(5 Pt 2), II28-II33 (1984-09-01)

Clonidine (Catapres, Catapresan), guanfacine (Estulic), and methyldopa (Aldomet) are the prototypes of centrally acting antihypertensive drugs. Clonidine and guanfacine are lipophilic drugs that readily penetrate into the brain, where they stimulate alpha-adrenergic receptors in the pontomedullary region. The stimulation of

Evaluation of an electrochemical biosensor for uric acid measurement in human whole blood samples.

Li-Ting Liao et al.

Clinica chimica acta; international journal of clinical chemistry, 436, 72-77 (2014-05-13)

Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a lack of

Global Trade Item Number

SKU	GTIN
1426002-500MG	04061833851883