UC126

4-Hydroxymephenytoin

Cytochrome P450 inhibitor, solid

• Synonym(s): (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylhydantoin, (±)-5-Ethyl-5-(4-hydroxyphenyl)-3-methylimididazolidine-2,4-dione
• Empirical Formula (Hill Notation): C₁₂H₁₄N₂O₃
• CAS Number: 61837-65-8
• Molecular Weight: 234.25
• UNSPSC Code: 12161501
• PubChem Substance ID: 24724640
• NACRES: NA.77
• MDL number: MFCD00142316
• Form: solid
• Quality level: 200

Properties

• Product Name: 4-Hydroxymephenytoin,
• form: solid
• Quality Level: 200
• color: white
• mp: 153-154 °C
• storage temp.: 2-8°C
• SMILES string: CCC1(NC(=O)N(C)C1=O)c2ccc(O)cc2
• InChI: 1S/C12H14N2O3/c1-3-12(8-4-6-9(15)7-5-8)10(16)14(2)11(17)13-12/h4-7,15H,3H2,1-2H3,(H,13,17)
• InChI key: OQPLORUDZLXXPD-UHFFFAOYSA-N

Description

General description

CYP2C19 metabolite of mephenytoin.

Application

4-Hydroxymephenytoin has been used for developing ultra performance LC (UPLC)- tandem mass spectrometry (MS/MS) assays for evaluating cytochrome P450 (CYP) probe drugs and their relevant metabolites in human urine or plasma samples[1]. 4-hydroxymephenytoin has also been used for developing sub-2-micron particle LC/MS/MS-based methods for analyzing CYP450 probe substrate metabolites[2].

Biochem/physiol Actions

4-Hydroxymephenytoin catabolism displays genetic polymorphism and is a direct indicator of Cytochrome P450 2C19 (CYP2C19) activity. Detection and quantification of 4-hydroxymephenytoin in biological samples by HPLC method is well optimized.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)