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apo-Transferrin bovine

Name: apo-Transferrin bovine
Brand: SIGMA

BioReagent, suitable for cell culture, ≥98%

Synonym(s):

Human serotransferrin

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About This Item

CAS Number:

11096-37-0

UNSPSC Code:

12352202

EC Number:

234-318-8

NACRES:

NA.83

MDL number:

MFCD00130536

eCl@ss:

34058011

Form:

powder

Assay:

≥98%

Biological source:

bovine

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Properties

biological source

bovine

Quality Level

200

product line

BioReagent

assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

iron, essentially free

solubility

H₂O: 10 mg/mL

UniProt accession no.

Q29443

storage temp.

2-8°C

Gene Information

bovine ... TF(280705)

Description

General description

apo-Transferrin is an iron-free form of transferrin that is present in circulation.[1]

Application

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.

apo-Transferrin bovine has been used as a component of:

basal medium for culturing bovine mammary epithelial cells[2][3]
minimum essential medium α (MEM-α) for spermatogonial stem cells (SSCs) culture[4]
induction medium for mesenchymal stem cell culture[5]

Biochem/physiol Actions

apo-Transferrin (apoTf) aids in preventing iron accumulation in tissues, especially in non-transfusion dependent β-thalassemia.[6]

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This Item	T1283	T2036	178481
Sigma-Aldrich T1428 apo-Transferrin bovine	Sigma-Aldrich T1283 holo-Transferrin bovine	Sigma-Aldrich T2036 apo-Transferrin human	Sigma-Aldrich 178481 Transferrin, Apo-, Low Endotoxin Grade, Human Plasma
biological source bovine	biological source -	biological source -	biological source -
assay ≥98%	assay 97-100% (agarose gel electrophoresis)	assay ≥98% (agarose gel electrophoresis)	assay ≥95% (SDS-PAGE)
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -
form powder	form powder	form powder	form lyophilized solid
impurities iron, essentially free	impurities endotoxin, tested	impurities HIV and HBsAg, source material tested negative, endotoxin, tested	impurities <0.1 EU/mg Endotoxins
UniProt accession no. Q29443	UniProt accession no. Q29443	UniProt accession no. P02787	UniProt accession no. -

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Effect of different exogenous fatty acids on the cytosolic triacylglycerol content in bovine mammary cells.

Einar Vargas-Bello-Pérez et al.

Animal nutrition (Zhongguo xu mu shou yi xue hui), 5(2), 202-208 (2019-06-14)

The objective of this study was to determine how cytosolic triacylglycerols (TAG) are stored in mammary cells and whether this depends on the individual chemical configuration of fatty acids (FA). This objective was accomplished by addition of different FA to

Facile uptake of manganese(III) by apotransferrin: possible origin of manganism.

Keita Abe et al.

Zeitschrift fur Naturforschung. C, Journal of biosciences, 63(1-2), 154-156 (2008-04-05)

We have investigated the mechanism of manganese ion uptake by apo-transferrin using a capillary electrophoresis method, and obtained clear evidence that oxidation state +3 and the binuclear unit of a manganese chelate are essential factors for the facile uptake by

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbbth3/+ (heterozygous B1/B2 globin gene deletion) mice.

Monique P Gelderman et al.

Haematologica, 100(5), 611-622 (2015-01-27)

Intermediate beta-thalassemia has a broad spectrum of sequelae and affected subjects may require occasional blood transfusions over their lifetime to correct anemia. Iron overload in intermediate beta-thalassemia results from a paradoxical intestinal absorption, iron release from macrophages and hepatocytes, and

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Global Trade Item Number

SKU	GTIN
T1428-500MG	04061837337444
T1428-10G	04061831169461
T1428-5G	04061833361306
T1428-50MG	04061833274392
T1428-100MG	04061833274378

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