This product is not classified as a Certified Reference Material (CRM) or a pharmaceutical secondary standard for product release testing, as these designations are not part of its specifications.
SML0148
Imidapril hydrochloride
≥98% (HPLC)
Synonym(s):
(4S)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride, Novaloc, TA 6366, Tanapril
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About This Item
Empirical Formula (Hill Notation):
C20H27N3O6 · HCl
CAS Number:
Molecular Weight:
441.91
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -50 to -70° in ethanol (c=0.5)
color
white to tan
solubility
H2O: ≥5 mg/mL
originator
Trinity Pharma Solutions
storage temp.
−20°C
SMILES string
Cl.CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2[C@@H](CN(C)C2=O)C(O)=O
InChI
1S/C20H27N3O6.ClH/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28;/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26);1H/t13-,15-,16-;/m0./s1
InChI key
LSLQGMMMRMDXHN-GEUPQXMHSA-N
General description
Imidapril comprises large acyl moiety and is hydrolyzed by carboxylesterase (CES) 1.[1]
Application
Imidapril hydrochloride may be used to test its effect on pharyngeal and laryngeal muscle to treat impaired swallowing.[2]
Imidapril hydrochloride was used as a standard in bioequivalence test by LC/MS method.[3]
Biochem/physiol Actions
Angiotensin Converting Enzyme (ACE) inhibitor
Imidapril hydrochloride is a long-acting inhibitor of angiotensin converting enzyme used in the treatment of hypertension, congestive heart failure and diabetic nephropathy.[4] It restores decreased airway sensation and bladder sensation in patients with multiple sclerosis.[4][5]
Imidapril is a potent angiotensin converting enzyme inhibitor and anti-hypertensive.
Features and Benefits
This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Trinity Pharma Solutions. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| form powder | form solid | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
| solubility H2O: ≥5 mg/mL | solubility H2O: >10 mg/mL | solubility H2O: >5 mg/mL | solubility DMSO: ~18 mg/mL |
| color white to tan | color white | color - | color white |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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