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S7635

Sigma-Aldrich

Sulforhodamine 101

Dye content ~95 %, Powder

Synonym(s):

SR101; 2-(3-oxa-23-aza-9-azoniaheptacyclo[17.7.1.15,9.02,17.04,15.023,27.013,28]octacosa-1(27),2(17),4,9(28),13,15,18-heptaen-16-yl)-5-sulfobenzenesulfonate

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About This Item

Empirical Formula (Hill Notation):
C31H30N2O7S2
CAS Number:
Molecular Weight:
606.71
Beilstein:
3582548
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

product name

Sulforhodamine 101, Dye content ~95 %

form

powder

Quality Level

composition

Dye content, ~95%

color

black
dark green to brown

solubility

methanol: 1 mg/mL

ε (extinction coefficient)

≥105000 at 573-579 nm in ethanol

fluorescence

λex 586 nm; λem 605 nm in H2O

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OS(=O)(=O)c1ccc(C2=C3C=C4CCC[N+]5=C4C(CCC5)=C3Oc6c7CCCN8CCCc(cc26)c78)c(c1)S([O-])(=O)=O

InChI

1S/C31H30N2O7S2/c34-41(35,36)20-9-10-21(26(17-20)42(37,38)39)27-24-15-18-5-1-11-32-13-3-7-22(28(18)32)30(24)40-31-23-8-4-14-33-12-2-6-19(29(23)33)16-25(27)31/h9-10,15-17H,1-8,11-14H2,(H-,34,35,36,37,38,39)

InChI key

COIVODZMVVUETJ-UHFFFAOYSA-N

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General description

Sulforhodamine 101 is a red fluorescent dye. It is water-soluble, amphoteric rhodamine.

Application

Sulforhodamine 101 has been used:
  • to label astrocytes
  • in quantitative polymerase chain reaction (PCR)
  • to determine the degree of disintegration in tissue sample

Biochem/physiol Actions

Sulforhodamine 101 can be specifically used as a marker of astroglia in the neocortex. It is commonly used for brain imaging. Studies suggest that sulforhodamine 101 may be used as an epileptogenic agent.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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In vivo imaging of oligodendrocytes with sulforhodamine 101
Hill RA and Grutzendler J
Nature Methods, 11(11), 1081-1081 (2014)
David S Greenberg et al.
Nature neuroscience, 11(7), 749-751 (2008-06-17)
It is unclear how the complex spatiotemporal organization of ongoing cortical neuronal activity recorded in anesthetized animals relates to the awake animal. We therefore used two-photon population calcium imaging in awake and subsequently anesthetized rats to follow action potential firing
Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
Nature Methods (2004)
Takashi Yoshida et al.
Nature communications, 11(1), 872-872 (2020-02-15)
Natural scenes sparsely activate neurons in the primary visual cortex (V1). However, how sparsely active neurons reliably represent complex natural images and how the information is optimally decoded from these representations have not been revealed. Using two-photon calcium imaging, we
Alex Plata et al.
Frontiers in molecular neuroscience, 11, 215-215 (2018-07-13)
Epilepsy is a group of neurological disorders commonly associated with the neuronal malfunction leading to generation of seizures. Recent reports point to a possible contribution of astrocytes into this pathology. We used the lithium-pilocarpine model of status epilepticus (SE) in

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