This product is not a sterile preparation. If the intended use, such as in cell culture, requires a sterile environment, then the stock solution would require filter sterilization. Typically, this is achieved by filtration through a 0.22 um membrane. Alternatively, product S9133 is a γ-irradiated, sterile powder. When reconstituted aseptically using sterile water, this product may be added directly to culture medium.
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https://www.sigmaaldrich.com/product/sigma/s9133
S5261
Sodium selenite
BioReagent, suitable for cell culture, ≥98%
Synonym(s):
Selenious acid, Sodium salt
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About This Item
Linear Formula:
Na2SeO3
CAS Number:
Molecular Weight:
172.94
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12352205
EC Number:
233-267-9
MDL number:
Pricing and availability is not currently available.
biological source
synthetic (inorganic)
Quality Level
product line
BioReagent
assay
≥98%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
>350 °C (lit.)
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES string
[Na+].[Na+].[O-][Se]([O-])=O
InChI
1S/2Na.H2O3Se/c;;1-4(2)3/h;;(H2,1,2,3)/q2*+1;/p-2
InChI key
BVTBRVFYZUCAKH-UHFFFAOYSA-L
Application
Sodium selenite is commonly used as a source of selenium in biological research, where selenium is an essential trace element that is normally provided by serum. Selenium is present in selenoproteins such as glutathione peroxidase and thioredoxin reductase, which contain the selenium analog of cysteine, selenocysteine. In particular, glutathione peroxidase has a role in detoxification in vivo as a scavenger of peroxides. Sodium selenite has been utilized in studies of cell proliferation and cancer research. It has been used to alter gene expression in HepG2 cells as analyzed by cDNA microarrays. Sodium selenite can inhibit zinc finger protein/DNA interactions. Sodium selenite has been shown to alter mitochondrial membrane potentials and thus potentially contribute to apoptosis.
This product is cell culture tested (0.005 mg/L) and is appropriate for use in cell culture applications.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form lyophilized powder | form - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable | technique(s) - |
| biological source synthetic (inorganic) | biological source - | biological source - | biological source - |
| solubility water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility - | solubility - | solubility - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| mp >350 °C (lit.) | mp >350 °C (lit.) | mp >350 °C (lit.) | mp >350 °C (lit.) |
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Danger
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
supp_hazards
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| S5261-25G | 04061835569403 |
| S5261-100G | 04061835569380 |
| S5261-10G | 04061835569397 |
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need filtration (0.2um) after preparation?
1 answer-
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How long does an aliquot of this product in water remain stable at -20 degrees Celsius?
1 answer-
As mentioned on the Product Datasheet, stock solutions of sodium selenite may be frozen. Working aliquots remain active for 30 days at 2-8 °C. The Datasheet can accessed in the DOCUMENTATION section under 'More Documents'. Please see the link below:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/245/224/s5261pis.pdfHelpful?
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What solvent do I need to use? DMSO OK?
1 answer-
This item is soluble in water at 50mg/mL. The solubility in DMSO as not been tested.
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