Key Documents

Sulfamonomethoxine

Name: Sulfamonomethoxine
Brand: SIGMA

Synonym(s):

4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide, 4-Methoxy-6-sulfanilamidopyrimidine, N¹-(6-Methoxy-4-pyrimidinyl)sulfanilamide, SMM

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₂N₄O₃S

CAS Number:

1220-83-3

Molecular Weight:

280.30

UNSPSC Code:

51283946

NACRES:

NA.85

PubChem Substance ID:

24899439

MDL number:

MFCD00063466

Beilstein/REAXYS Number:

621128

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Properties

form

powder

Quality Segment

200

color

white to yellow-white

solubility

methanol: soluble 10 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, parasites

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1

InChI

1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)

InChI key

WMPXPUYPYQKQCX-UHFFFAOYSA-N

Description

General description

Chemical structure: sulfonamide

Application

Sulfamonomethoxine is used to study degradation by Fe³O⁴ magnetic nanoparticles[1]. It is used in blood kinetic studies and is used to study capsule formation of Bordetella bronchiseptica[2][3].

Biochem/physiol Actions

Sulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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1 of 1

This Item	S6256	32091	S5637
Sigma-Aldrich S0508 Sulfamonomethoxine	Sigma-Aldrich S6256 Sulfamethazine	Supelco 32091 Sulfamonomethoxine	Sigma-Aldrich S5637 Sulfamethazine sodium salt
antibiotic activity spectrum Gram-negative bacteria, parasites, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria	antibiotic activity spectrum -	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria
mode of action enzyme \| inhibits, DNA synthesis \| interferes	mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action -	mode of action DNA synthesis \| interferes, enzyme \| inhibits
form powder	form powder or crystals	form -	form powder
solubility methanol: soluble 10 mg/mL	solubility -	solubility -	solubility H₂O: soluble 50 mg/mL
color white to yellow-white	color white to off-white	color -	color white to off-white
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200

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pictograms

GHS07

signalword

Warning

hcodes

H315,H317,H319,H335

pcodes

P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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