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N6664

Neurodazine

≥98% (HPLC)

Synonym(s):

2-[5-(3-Chlorophenyl)-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H imidazole

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About This Item

Empirical Formula (Hill Notation):
C27H21ClN2O3
CAS Number:
937807-66-4
Molecular Weight:
456.92
NACRES:
NA.25
PubChem Substance ID:
329818668
UNSPSC Code:
12352203
MDL number:
MFCD08906055
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1)-c2nc([nH]c2-c3ccc(OC)cc3)-c4ccc(o4)-c5cccc(Cl)c5

InChI

1S/C27H21ClN2O3/c1-31-21-10-6-17(7-11-21)25-26(18-8-12-22(32-2)13-9-18)30-27(29-25)24-15-14-23(33-24)19-4-3-5-20(28)16-19/h3-16H,1-2H3,(H,29,30)

InChI key

FEEOFPAEDSMOTO-UHFFFAOYSA-N

Biochem/physiol Actions

Neurodazine is a promoter of neurogenesis. It induces a generation of new nerve cells from skeletal muscle fibers both immature, differentiated myotubes and mature skeletal muscle. Neurodazine promotes the expression of neuron-specific markers in treated C2C12 cells (neurogenesis). In addition, in conjunction with a microtubule-destabilizing agent, Neurodazine allows neurogenic conversion of both differentiated immature myotubes and mature skeletal muscle. Neurodazine is a potential alternative approach to using stem cells.
Neurodazine is a promoter of neurogenesis; induces generation of new nerve cells from skeletal muscle fibers both immature differentiated myotubes and mature skeletal muscle; a potential alternative approach to using stem cells.

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This Item
SML2379N6287SML0580
Neurodazine ≥98% (HPLC)

Sigma-Aldrich

N6664

Neurodazine

Fluorizoline ≥98% (HPLC)

Sigma-Aldrich

SML2379

Fluorizoline

Nutlin-3 ≥98% (HPLC), powder

Sigma-Aldrich

N6287

Nutlin-3

Nutlin-3a ≥98% (HPLC)

Sigma-Aldrich

SML0580

Nutlin-3a

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: >20 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, H2O: insoluble

solubility

DMSO: 5 mg/mL, clear

color

yellow

color

white to beige

color

-

color

white to beige

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pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Dam. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000101222
0000076999
0000076998
039K4610

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Ronald W Irwin et al.
Frontiers in endocrinology, 2, 117-117 (2011-01-01)
The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer's disease (AD) brains. In parallel, the neuroactive progesterone metabolite, allopregnanolone (APα), along with a host of
Jun Ding et al.
Journal of Alzheimer's disease : JAD, 37(3), 587-592 (2013-08-21)
Ciliary neurotrophic factor (CNTF) is a pleiotropic cytokine that has been fully studied for its structure, receptor, and signaling pathways and its multiplex effects on neural system, skeletal muscle, and weight control. Recent research demonstrates that CNTF also plays an

Global Trade Item Number

SKUGTIN
N6664-5MG04061833235072
N6664-25MG04061832272733

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