M8527

4-Methylumbelliferyl α-L-fucopyranoside

fluorogenic, ≥97% (TLC), powder

• Synonym(s): 4-Methylumbelliferyl alpha-L-fucopyranoside
• Empirical Formula (Hill Notation): C₁₆H₁₈O₇
• CAS Number: 54322-38-2
• Molecular Weight: 322.31
• NACRES: NA.21
• PubChem Substance ID: 24897268
• UNSPSC Code: 12352204
• EC Number: 259-098-0
• MDL number: MFCD00051218
• Beilstein/REAXYS Number: 8160514

Properties

• Product Name: 4-Methylumbelliferyl α-L-fucopyranoside, ≥97% (TLC)
• Quality Segment: 200
• assay: ≥97% (TLC)
• form: powder
• solubility: DMF: 100 mg/mL, clear, colorless to faintly yellow
• fluorescence: λ_ex 360 nm; λ_em 449 nm (Reaction product)
• storage temp.: −20°C
• SMILES string: C[C@@H]1O[C@@H](Oc2ccc3C(C)=CC(=O)Oc3c2)[C@@H](O)[C@H](O)[C@@H]1O
• InChI: 1S/C16H18O7/c1-7-5-12(17)23-11-6-9(3-4-10(7)11)22-16-15(20)14(19)13(18)8(2)21-16/h3-6,8,13-16,18-20H,1-2H3/t8-,13+,14+,15-,16-/m0/s1
• InChI key: CQKHENXHLAUMBH-CRLRYRHBSA-N

Description

General description

Substrate for α-L-fucosidase

Application

4-Methylumbelliferyl α-L-fucopyranoside has been used:

• as a substrate in α-L-fucosidase 1 (α-L-FUCA-1) enzyme assays to convert it to the fluorescent product 4-methylumbelliferone (4MU) for finding the distribution of the membrane-associated α-L-FUCA-1 of human sperm[1]
• as a fluorogenic substrate in enzyme assays to evaluate the stability of both the seminal plasma and membrane-associated α-l-fucosidase[2]
• as a substrate to measure the enzymatic activity of α-L-FUCA-1 of cell extracts from TPC-1, BCPAP, 8505C, and CAL62 cell lines[3]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)