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F0504

Folate binding protein from bovine milk

lyophilized powder

Synonym(s):

Folate Protein

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131098
Form:
lyophilized powder
Biological source:
bovine milk
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biological source

bovine milk

Quality Level

200

form

lyophilized powder

usage

 mg sufficient for ~4,000 assays

composition

Protein, 20-40% modified Warburg-Christian

technique(s)

ligand binding assay: suitable, surface plasmon resonance (SPR): suitable

capacity

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

storage temp.

−20°C

Application

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.[1][2][3]
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.

Biochem/physiol Actions

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing buffer salt as sodium citrate

Analysis Note

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

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Folate binding protein from bovine milk lyophilized powder

Sigma-Aldrich

F0504

Folate binding protein from bovine milk

α-Casein Dephosphorylated from bovine milk lyophilized powder

Sigma-Aldrich

C8032

α-Casein Dephosphorylated from bovine milk

Bovine Serum Albumin lyophilized powder, protease, essentially free, ≥98% (agarose gel electrophoresis)

Sigma-Aldrich

A4737

Bovine Serum Albumin

Bovine Serum Albumin heat shock fraction, protease free, fatty acid free, essentially globulin free, pH 7, ≥98%

Sigma-Aldrich

A7030

Bovine Serum Albumin

biological source

bovine milk

biological source

bovine milk

biological source

bovine

biological source

bovine

technique(s)

ligand binding assay: suitable, surface plasmon resonance (SPR): suitable

technique(s)

surface plasmon resonance (SPR): suitable

technique(s)

ligand binding assay: suitable

technique(s)

ELISA: suitable, blood typing: suitable, ligand binding assay: suitable

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

capacity

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

capacity

-

capacity

-

capacity

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000387622
0000316185
0000316185
0000387622
051M7670V

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Nikki Parker et al.
Analytical biochemistry, 338(2), 284-293 (2005-03-05)
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety of cancers. The current development of folate-targeted cancer therapies has created the need for quantitating functional FRs in clinical specimens. In this article, we
The binding of folic acid and 5-methyltetrahydrofolate to folate-binding proteins during gastric passage differs in a dynamic in vitro gastrointestinal model
Verwei M, et al.
The Journal of Nutrition, 134(1), 31-37 (2004)
Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein
Jones ML and Nixon PF
The Journal of Nutrition, 132(9), 2690-2694 (2002)
View All Related Papers

Global Trade Item Number

SKUGTIN
F0504-1MG04061826744550
F0504-5MG04061833261590

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