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E8515

β-Estradiol 3-benzoate

≥97%

Synonym(s):

1,3,5(10)-Estratriene-3,17β-diol 3-benzoate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-benzoate, 3-Benzoyloxy-17β-estrol

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About This Item

Empirical Formula (Hill Notation):
C25H28O3
CAS Number:
Molecular Weight:
376.49
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-043-7
Beilstein/REAXYS Number:
3107526
MDL number:
Assay:
≥97%
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Quality Segment

assay

≥97%

mp

191-198 °C (lit.)

SMILES string

[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OC(=O)c5ccccc5)ccc24

InChI

1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1

InChI key

UYIFTLBWAOGQBI-BZDYCCQFSA-N

Application

β-Estradiol 3-benzoate has been used:to mimic estradiol in rat during the oestrous cycle in rats. It has also been used along with progesterone for the induction of sexual receptivity in female rat.[1]
Used in a study of general steroid metabolism and clearing, as groundwork for anabolic steroid screening in athletes.

Biochem/physiol Actions

β-Estradiol 3-benzoate is a synthetic estrogen. It favors breast cancer progression. It is an endocrine disrupting chemicals. It interacts with endocrine system and cause harmful effect on reproduction in animals and humans. It binds to estrogen receptors and favors tumor metastatis in breast, prostate and bone cells.

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This Item
E1024E1132E2127
assay

≥97%

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mp

191-198 °C (lit.)

mp

176-180 °C (lit.)

mp

176-180 °C (lit.)

mp

-


pictograms

Health hazard

signalword

Danger

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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Global Trade Item Number

SKUGTIN
E8515-1G04061833608753
E8515-5G04061833608777
E8515-200MG04061833608760

Questions

1–2 of 2 Questions  
  1. If dissolved in corn oil, how is the stability? What is the recommended storage temperature and duration?

    1 answer
    1. The stability of this product in corn oil has not been investigated. However, various external sources indicate that Estradiol benzoate may be stored in aliquots at -80°C for 2 years and -20°C for 1 year when prepared at 2.5 mg/mL or greater in a mixture of 1 part DMSO and 9 parts corn oil.

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  2. How should stock solutions for the product β-Estradiol 3-benzoate (E8515) be stored?

    1 answer
    1. Once the solution is prepared, it should be stored in separate packages to prevent product failure due to repeated freezing and thawing. The recommended storage period for the stock solution is as follows: when stored at -80°C, it should be used within 6 months; when stored at -20°C, it should be used within 1 month. To enhance solubility, the tube can be heated to 37°C and then agitated in an ultrasonic bath for a period of time.

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