D8388
Dimethyl pimelimidate dihydrochloride
powder
Synonym(s):
DMP, Dimethyl pimelinediimidate dihydrochloride
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About This Item
Linear Formula:
[CH3OC(=NH)CH2CH2]2CH2 · 2HCl
CAS Number:
Molecular Weight:
259.17
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
261-320-6
MDL number:
Form:
powder
Pricing and availability is not currently available.
form
powder
Quality Level
reaction suitability
reagent type: cross-linking reagent
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
Cl.Cl.COC(=N)CCCCCC(=N)OC
InChI
1S/C9H18N2O2.2ClH/c1-12-8(10)6-4-3-5-7-9(11)13-2;;/h10-11H,3-7H2,1-2H3;2*1H
InChI key
LRHXBHUTQWIZTN-UHFFFAOYSA-N
General description
Dimethyl pimelimidate dihydrochloride is a homobifunctional cross-linking reagent used in crosslinking, protein interaction and protein modification. It typically reacts with primary amines in the pH range 7.0-10.0 to form amidine bonds.
Application
Dimethyl pimelimidate dihydrochloride has been used to develop a technique for isolating Enterocytozoon bieneusi spores directly from human stool samples with a high degree of purity, which opens up new approaches for studying this parasite.
Other Notes
Note that the amidine linkage preserves original primary amine positive charge. Incorporates a seven atom linker.
Disclaimer
The reagent is readily hydrolyzed at neutral pH.
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This Item | |||
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| solubility H2O: 10 mg/mL | solubility - | solubility - | solubility - |
| reaction suitability reagent type: cross-linking reagent | reaction suitability - | reaction suitability - | reaction suitability - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form liquid | form powder |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-30°C | storage temp. - |
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signalword
Warning
hcodes
Hazard Classifications
Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Related Content
Kevin Michael Boehm et al.
BMC bioinformatics, 20(1), 7-7 (2019-01-07)
To further our understanding of immunopeptidomics, improved tools are needed to identify peptides presented by major histocompatibility complex class I (MHC-I). Many existing tools are limited by their reliance upon chemical affinity data, which is less biologically relevant than sampling
K Brew et al.
The Journal of biological chemistry, 250(4), 1434-1444 (1975-02-25)
The cross-linking of the two components of lactose synthetase, alpha-lactalbumin and a galactosyltransferase, with dimethylpimelimidate was examined. The extent of the cross-linking at pH 8.1 was found to be dependent upon the presence of substrates or inhibitors for the galactosyltransferase.
G B Karlsson et al.
Analytical biochemistry, 199(2), 219-222 (1991-12-01)
A method is described for the use of magnetic beads as a solid phase for the immunoprecipitation of labeled proteins. The anti-human transferrin receptor monoclonal antibody OKT-9 has been coupled to sheep anti-mouse IgG1-coated magnetic beads using the crosslinking agent
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D8388-25G | 04061833662762 |
| D8388-250MG | 04061833589502 |
| D8388-5G | 04061833589519 |
| D8388-1G | 04061833589496 |