Compound 48/80

Name: Compound 48/80
Brand: SIGMA

powder, hypotensive agent

Synonym(s):

Poly-p-methoxyphenethylmethylamine

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About This Item

UNSPSC Code:

41106300

NACRES:

NA.77

Form:

powder

Quality level:

200

Pricing and availability is not currently available.

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Properties

Product Name

Compound 48/80,

form

powder

Quality Level

200

solubility

H₂O: 50 mg/mL

storage temp.

−20°C

Description

General description

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

Application

Compound 48/80 has been used:

to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
to induce mast cell degranulation
to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice

Biochem/physiol Actions

Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca²⁺ ATPase and activates G proteins.

Preparation Note

Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.

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This Item	352010	499635	385570
Sigma-Aldrich C2313 Compound 48/80	Sigma-Aldrich 352010 Glutaminase Inhibitor, Compound 968	Sigma-Aldrich 499635 OSC Inhibitor, Ro 48-8071	Sigma-Aldrich 385570 Heat Shock Factor 1 Inhibitor, KRIBB11
form powder	form powder	form solid	form solid
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility H₂O: 50 mg/mL	solubility DMSO: 5 mg/mL	solubility water: 5 mg/mL	solubility DMSO: 50 mg/mL, brown