The stability of this compound in solution has not been determined. However, other sources report that stock solutions prepared in DMSO may be stable for up to 1 year at –20 °C and up to 2 years at –80 °C. When diluted to working concentrations with aqueous medium or buffers, it is not recommended to store solutions for more that 1 day. This information has not been validated.
A1737
A922500
synthetic (organic), >95% (HPLC), Diacylglycerol acyltransferase inhibitor, powder
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About This Item
Empirical Formula (Hill Notation):
C26H24N2O4
CAS Number:
Molecular Weight:
428.48
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.77
Pricing and availability is not currently available.
Product Name
A922500,
biological source
synthetic (organic)
Quality Level
assay
>95% (HPLC)
form
powder
mol wt
Mw 428.5
solubility
DMSO: 10 mg/mL, clear, colorless to greenish-yellow
storage temp.
−20°C
SMILES string
N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
InChI
1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
InChI key
BOZRFEQDOFSZBV-DHIUTWEWSA-N
Application
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
Biochem/physiol Actions
Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC50 7 to 24 nM
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease. [1]
Physical form
A922500 is supplied as a crystalline solid.
Preparation Note
A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
1 of 1
This Item | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) |
| assay >95% (HPLC) | assay ≥95% | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| form powder | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. - | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: 10 mg/mL, clear, colorless to greenish-yellow | solubility DMF: 20 mg/mL, clear to slightly hazy, colorless to light yellow | solubility water: 50 mg/mL, clear, colorless to faintly yellow | solubility water: 50 mg/mL, clear, colorless to yellow |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis
Leiguez E, et al.
Mediators of Inflammation, 2018 (2018)
Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
Jarc E, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(3), 247-265 (2018)
A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program
Giudetti AM, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(3), 344-357 (2019)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A1737-10MG | 04061833228005 |
| A1737-1MG | 04061833342916 |
| A1737-5MG | 04061833228012 |
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Once the compound is dissolved in DMSO, I prepared a dilution in serum-free DMEM. How long can I store it at 4 °C while maintaining its stability?
1 answer-
Helpful?
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What is the half life of the inhibitor
1 answer-
The half life of this inhibitor has not been determined.
Helpful?
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Hello, in your description sector, it says this product can be dissolved in ethanol. However I have checked other sources that say A922500 is insoluble in ethanol. Could you clarify this for me?
1 answer-
This product is tested for solubility in DMSO at 10 mg/mL. The material is less soluble in ethanol at approximately 200 ug/mL. In addition, this compound may be dissolved in dimethylformamide at 20 mg/mL.
Helpful?
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