A0550

Ala-Gln

≥98% (HPLC)

• Synonym(s): Alanyl-glutamine, Glutamine-S
• Empirical Formula (Hill Notation): C₈H₁₅N₃O₄
• CAS Number: 39537-23-0
• Molecular Weight: 217.22
• UNSPSC Code: 12352209
• PubChem Substance ID: 24890433
• NACRES: NA.26

Properties

• Product Name: Ala-Gln, ≥98% (HPLC)
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• SMILES string: NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O
• InChI: 1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
• InChI key: HJCMDXDYPOUFDY-WHFBIAKZSA-N

Description

Application

L-Glutamine is an essential supplement for cell culture. The free amino acid L-glutamine is unstable and degrades to pyroglutamate. Alanyl-L-glutamine (Ala-Gln) and Gylcyl-L-glutamine (Gly-Gln) are used in cell culture as alternative delivery forms of stabilized L-glutamine. The primary advantage of using L-alanylglutamine in place of L-glutamine is that it reduces the level of ammonia generated during cell culture.[1][2]

Biochem/physiol Actions

Alanyl-glutamine is a widely used alternative supplement to L-glutamine in the production of biopharmaceuticals. Alanyl-glutamine also acts as an antioxidant (peroxide) and anti-apoptosis (LPS-induced) factor. Ala-Gln has been used in studies on injury and sepsis, and on the effects of irradiation on leucine and protein metabolism in vivo.[3][4] Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro.[5]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)