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328634

NMP

anhydrous, 99.5%

1-Methyl-2-pyrrolidinone
1 of 1 reviewers took part in a promotion

Synonym(s):

1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

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About This Item

Empirical Formula (Hill Notation):
C5H9NO
CAS Number:
Molecular Weight:
99.13
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352005
EC Number:
212-828-1
MDL number:
Beilstein/REAXYS Number:
106420
Assay:
99.5%
Grade:
anhydrous
Bp:
202 °C (lit.), 81-82 °C/10 mmHg (lit.)
Vapor pressure:
0.29 mmHg ( 20 °C), 0.99 mmHg ( 40 °C)
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Product Name

1-Methyl-2-pyrrolidinone, anhydrous, 99.5%

grade

anhydrous

Quality Level

vapor density

3.4 (vs air)

vapor pressure

0.29 mmHg ( 20 °C), 0.99 mmHg ( 40 °C)

assay

99.5%

form

liquid

autoignition temp.

518 °F

expl. lim.

9.5 %

impurities

<0.005% water

refractive index

n20/D 1.47 (lit.)

pH

7.7-10.0 (20 °C, 100 g/L)

bp

202 °C (lit.), 81-82 °C/10 mmHg (lit.)

mp

−24 °C (lit.)

density

1.028 g/mL at 25 °C (lit.)

SMILES string

CN1CCCC1=O

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

Application

1-Methyl-2-pyrrolidinone may be used as a solvent in the following processes:
  • Preparation of 2-aryl and 2-alkyl benzothiazoles.
  • Ullmann coupling reaction of aryl halides and phenols to form Ullmann ethers in the presence of 2,2,6,6-tetramethylheptane-3,5-dione.
  • Stille cross-coupling reaction of aryl iodides with organostannanes catalyzed by Pd/C in the presence of copper iodide as cocatalyst.

Other Notes

Pure-Pac® II containers require the Micromatic MacroValve coupler for dispensing solvents, Z560723.

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

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5.8959719-4060494496
assay

99.5%

assay

99.5%

assay

≥98.0%

assay

≥99.7%

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

100

grade

anhydrous

grade

anhydrous

grade

SAJ first grade

grade

biotech. grade

form

liquid

form

-

form

liquid

form

-

refractive index

n20/D 1.47 (lit.)

refractive index

n20/D 1.47 (lit.)

refractive index

n20/D 1.47 (lit.)

refractive index

n20/D 1.47 (lit.)

autoignition temp.

518 °F

autoignition temp.

518 °F

autoignition temp.

518 °F

autoignition temp.

518 °F


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter



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Stille couplings catalyzed by palladium-on-carbon with CuI as a cocatalyst: Synthesis of 2-(4'-acetylphenyl)thiophene
Liebeskind LS and Pe?a-Cabrera E
Organic Syntheses, 77, 135-135 (2000)
Guohua Hu et al.
Nature communications, 8(1), 278-278 (2017-08-19)
Black phosphorus is a two-dimensional material of great interest, in part because of its high carrier mobility and thickness dependent direct bandgap. However, its instability under ambient conditions limits material deposition options for device fabrication. Here we show a black
Densities, viscosities, speeds of sound, and relative permittivities for water+ cyclic amides (2-pyrrolidinone, 1-methyl-2-pyrrolidinone, and 1-vinyl-2-pyrrolidinone) at different temperatures.
George J and Sastry NV.
Journal of Chemical and Engineering Data, 49(2), 235-242 (2004)



Global Trade Item Number

SKUGTIN
328634-1L04061837533358
328634-100ML04061837533334
328634-6X1L04061826717684
328634-200L04061836608484
328634-4X2L04061826717677
328634-PH-20L-P204065268977750
328634-18L-P104061826717660
328634-2L04061837533365
328634-12X100ML04061837533341
328634-50L-P204061838161536

Questions

1–7 of 7 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. Is NMP compatible with PTFE?

    1 answer
    1. N-Methylpyrrolidone (NMP) is a commonly used solvent, and it is compatible with polytetrafluoroethylene (PTFE).

      Helpful?

  3. Is NMP supplied under N2 or air?

    1 answer
    1. This product is packaged under nitrogen.

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  5. Is this NMP suitable for HPLC and GC analysis?

    1 answer
    1. Yes, this product is suitable for HPLC and GC analysis. This anhydrous NMP can be effectively used in environments where moisture must be minimized, which is often critical in analytical techniques like HPLC and GC.

      Helpful?

  6. Does it have molecular shieve in the bottle?

    1 answer
    1. Molecular sieves are not included with this anhydrous material. However, the 18L size is packaged in the Pure-Pac II container, and the 100 mL to 2L volumes utilize Sure/Seal closures. Please see the links below to learn more about each package type:

      Sure/Seal
      https://www.sigmaaldrich.com/technical-documents/technical-article/chemistry-and-synthesis/organic-reaction-toolbox/sureseal

      Pure-Pac
      https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/391/402/al_techbull_al201.pdf

      Helpful?

  7. Could you please provide me with the dimensions of the bottle containing the product 328634-2L (1-Methyl-2-pyrrolidinone)?

    1 answer
    1. The packaging description for the bottle is as follows:
      • Bottle Type: Narrow Neck Glass Bottle
      • Capacity: 2500 ml (Nominal), 2750 ml (Brimful)
      • Closure Type: Crown Cap (Sure/Seal)
      • Glass Type: Amber Glass (Hydrolytic Class III)
      • Diameter: 139 mm
      • Height: 286 mm
      • Height with Cap: 293 mm
      • Thread Diameter: 32 mm
      • Thread Type: 32 mm
      • Inner Diameter of Opening: 17 mm

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Reviews

1 of 1 reviewers took part in a promotion

Active Filters

  1. boston, ma
    • Reviews 2
    • Votes 4
    4 out of 5 stars.

    nice but also

    good product, but inconsistent stock. Many times unavailable.

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