T7205

Tegafur

powder

• Synonym(s): 5-Fluoro-1-(tetrahydro-2-furyl)uracil, Ftorafur, Tegafur
• Empirical Formula (Hill Notation): C₈H₉FN₂O₃
• CAS Number: 17902-23-7
• Molecular Weight: 200.17
• NACRES: NA.77
• PubChem Substance ID: 329826861
• UNSPSC Code: 12352200
• EC Number: 241-846-2
• MDL number: MFCD00012351
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• mp: 171-173 °C (lit.)
• solubility: DMSO: >50 mg/mL
• storage temp.: room temp
• SMILES string: FC1=CN(C2CCCO2)C(=O)NC1=O
• InChI: 1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
• InChI key: WFWLQNSHRPWKFK-UHFFFAOYSA-N

Description

Application

Tegafur has been used as an internal standard for the analysis of 5′DFCR (5′deoxyfluorocytidine) and 5′DFUR (5′deoxyfluorouridine) using HPLC techniques[1]. Tegafur has also been used as an internal standard for the chromatographic assay of azidothymidine (AZT)[2].

Biochem/physiol Actions

Tegafur is a pro-drug of 5-fluorouracil, an antimetabolite used as an antineoplastic agent. It has been used as adjuvant chemotherapy for curatively resected colorectal cancer therapy.

Preparation Note

Tegafur is soluble in DMSO at a concentration that is greater than 50 mg/ml.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable