T2376

L-Thyroxine

synthetic, ≥98% (HPLC), Metabolism activator, powder

• Synonym(s): 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄
• Linear Formula: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• CAS Number: 51-48-9
• Molecular Weight: 776.87
• NACRES: NA.32
• PubChem Substance ID: 24900033
• UNSPSC Code: 51111800
• EC Number: 200-101-1
• MDL number: MFCD00002595
• Beilstein/REAXYS Number: 2228515
• eCl@ss: 32190102
• Biological source: synthetic
• Form: powder
• Assay: ≥98% (HPLC)

Properties

• Product Name: L-Thyroxine, ≥98% (HPLC)
• biological source: synthetic
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥98% (HPLC)
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: 223 °C (dec.) (lit.)
• solubility: 4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow
• shipped in: ambient
• storage temp.: room temp
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
• InChI key: XUIIKFGFIJCVMT-LBPRGKRZSA-N
• Gene Information: human ... THRA(7067), THRB(7068), TTR(7276) ; mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Description

Application

L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail.[1] The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.[2]

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H372
• pcodes: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• target_organs: Thyroid,Cardio-vascular system,Kidney
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)