This product is not a pharmaceutical grade item, it is intended for research use only. Currently, a pharmaceutical grade Tolfernamic acid is not offered.
T0535
Tolfenamic acid
NSAID
Synonym(s):
2 (3-Chloro-2-methylanilino)benzoic acid, 2-([3-Chloro-2-methylphenyl]amino)benzoic acid
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About This Item
Empirical Formula (Hill Notation):
C14H12ClNO2
CAS Number:
Molecular Weight:
261.70
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
237-264-3
MDL number:
Pricing and availability is not currently available.
Quality Segment
assay
≥98% (TLC)
form
powder
solubility
ethanol: 50 mg/mL, clear, greenish-yellow
SMILES string
Cc1c(Cl)cccc1Nc2ccccc2C(O)=O
InChI
1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18)
InChI key
YEZNLOUZAIOMLT-UHFFFAOYSA-N
General description
Tolfenamic acid is a fenamate and is made up of a monocarboxylate diphenylamine nucleus.
Application
Tolfenamic acid has been used in Arabidopsis bud assay for activity comparison with quinazolinedione derivatives (QADD) based compounds.
Biochem/physiol Actions
Tolfenamic acid is involved in the inhibition of prostaglandin synthesis. It also plays a role in apoptosis of head and neck cancer cells.[1]
Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor.
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| assay ≥98% (TLC) | assay - | assay - | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 100 |
| form powder | form - | form - | form powder |
| solubility ethanol: 50 mg/mL, clear, greenish-yellow | solubility - | solubility - | solubility DMSO: 2 mg/mL, clear |
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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I am a research pharmacist looking for a source of pharmaceutical-grade tolfenamic acid. Is this powder pharmaceutical grade, and acceptable for use in humans after compounding into tablets/capsules?
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