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N8028

Nikkomycin Z from Streptomyces tendae

≥90% (HPLC)

Synonym(s):

Neopolyoxin C, Nikkomycin Z

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About This Item

Empirical Formula (Hill Notation):
C20H25N5O10
CAS Number:
59456-70-1
Molecular Weight:
495.44
NACRES:
NA.85
PubChem Substance ID:
24897849
UNSPSC Code:
51102829
MDL number:
MFCD00869648
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Quality Segment

200

assay

≥90% (HPLC)

form

powder

solubility

H2O: soluble 5 mg/mL

antibiotic activity spectrum

fungi

mode of action

cell wall synthesis | interferes, enzyme | inhibits

storage temp.

2-8°C

SMILES string

C[C@@H]([C@H](N)C(=O)N[C@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O)C(O)=O)[C@H](O)c3ccc(O)cn3

InChI

1S/C20H25N5O10/c1-7(13(28)9-3-2-8(26)6-22-9)11(21)17(31)24-12(19(32)33)16-14(29)15(30)18(35-16)25-5-4-10(27)23-20(25)34/h2-7,11-16,18,26,28-30H,21H2,1H3,(H,24,31)(H,32,33)(H,23,27,34)/t7-,11-,12+,13-,14-,15+,16+,18+/m0/s1

InChI key

WWJFFVUVFNBJTN-JKEIIPFCSA-N

General description

Chemical structure: peptidyl nucleoside

Application

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species[1] and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure[2].

Biochem/physiol Actions

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine[3].

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

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This Item
S855974667P9620
Nikkomycin Z from Streptomyces tendae ≥90% (HPLC)

Sigma-Aldrich

N8028

Nikkomycin Z from Streptomyces tendae

Sinefungin 95% (HPLC), powder

Sigma-Aldrich

S8559

Sinefungin

Nourseothricin sulfate ≥85% (HPLC)

Sigma-Aldrich

74667

Nourseothricin sulfate

Puromycin dihydrochloride Ready Made Solution, from Streptomyces alboniger, 10 mg/mL in H2O, suitable for cell culture

Sigma-Aldrich

P9620

Puromycin dihydrochloride

mode of action

cell wall synthesis | interferes, enzyme | inhibits

mode of action

DNA synthesis | interferes, enzyme | inhibits

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

antibiotic activity spectrum

fungi

antibiotic activity spectrum

neoplastics

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, mycobacteria, mycoplasma, parasites, viruses, yeast

antibiotic activity spectrum

Gram-positive bacteria, neoplastics, parasites

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

300

form

powder

form

powder

form

solid

form

ready-to-use solution

assay

≥90% (HPLC)

assay

95% (HPLC)

assay

≥85% (HPLC)

assay

>98% (HPLC)

solubility

H2O: soluble 5 mg/mL

solubility

H2O: complete 20 mg/ml, clear, colorless to light yellow, H2O: soluble

solubility

H2O: soluble 200 mg/mL

solubility

H2O: soluble 10 mg/mL

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000485855
0000485855
0000455821
0000455821
0000402991

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Global Trade Item Number

SKUGTIN
N8028-5MG04061834118367

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