Key Documents

Mdivi-1

Name: Mdivi-1
Brand: SIGMA

≥98% (HPLC), powder, mitochondrial division DRP inhibitor

Synonym(s):

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀Cl₂N₂O₂S

CAS Number:

338967-87-6

Molecular Weight:

353.22

UNSPSC Code:

12352200

PubChem Substance ID:

329817738

NACRES:

NA.77

MDL number:

MFCD00974506

Assay:

≥98% (HPLC)

Form:

powder

Pricing and availability is not currently available.

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Properties

Product Name

Mdivi-1, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >20 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl

InChI

1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)

InChI key

NZJKEVWTYMOYOR-UHFFFAOYSA-N

Description

General description

Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.

Application

Mdivi-1 has been used:

in embryonic thoracic aorta A7r5 cells to inhibit cell migration and proliferation[1]
in mitochondrial network reshaping and reactive oxygen species (ROS) production studies in oligodendrocyte precursor cells (OPCs)[2]
to induce mitochondrial damage in lung fibroblasts

Biochem/physiol Actions

Mdivi-1 is a cell-permeable selective inhibitor of mitochondrial division DRP (dynamin-related GTPase) and inhibitor of the mitochondrial division dynamin (Dnm1). Mitochondrial fusion and division play important roles in the regulation of apoptosis. Mdivi-1 is the first selective inhibitor of mitochondrial division dynamins. In principle, Mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.

Mdivi-1 is a selective inhibitor of mitochondrial division DRP (dynamin-related GTPase); inhibitor of the mitochondrial division dynamin (Dnm1).

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

1 of 1

This Item	475856	SML0599	SML0607
Sigma-Aldrich M0199 Mdivi-1	Sigma-Aldrich 475856 Mitochondrial Division Inhibitor, mdivi-1	Sigma-Aldrich SML0599 DIF-1	Sigma-Aldrich SML0607 Ceranib-2
assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form solid	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: >20 mg/mL	solubility DMSO: 10 mg/mL	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 20 mg/mL, clear
shipped in wet ice	shipped in wet ice	shipped in -	shipped in wet ice

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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