Skip to Content
Merck

Key Documents

View All Documentation

Skip To

C223

Cirazoline hydrochloride

solid

Synonym(s):

2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C13H16N2O · HCl
CAS Number:
40600-13-3
Molecular Weight:
252.74
NACRES:
NA.77
PubChem Substance ID:
24277770
UNSPSC Code:
12352200
EC Number:
254-995-3
MDL number:
MFCD00274034
Form:
solid
Quality level:
100
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

form

solid

Quality Level

100

color

white

solubility

H2O: >35 mg/mL

SMILES string

Cl[H].C1CN=C(COc2ccccc2C3CC3)N1

InChI

1S/C13H16N2O.ClH/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13;/h1-4,10H,5-9H2,(H,14,15);1H

InChI key

XFRXWLWUUDJHPB-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Application

Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.[1]

Biochem/physiol Actions

Cirazoline is a selective α1-adrenoceptor agonist and also a non-selective ligand for the imidazoline binding site. Cirazoline dereases spatial working memory performance in aged monkeys.[2]

Features and Benefits

This compound is featured on the α1-Adrenoceptors and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
T4264T6950SML1821
Cirazoline hydrochloride solid

Sigma-Aldrich

C223

Cirazoline hydrochloride

Tetrahydrozoline hydrochloride ≥98% (HPLC)

Sigma-Aldrich

T4264

Tetrahydrozoline hydrochloride

Tizanidine hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

T6950

Tizanidine hydrochloride

Imidafenacin hydrochloride ≥95% (HPLC)

Sigma-Aldrich

SML1821

Imidafenacin hydrochloride

form

solid

form

-

form

powder

form

powder

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

solubility

H2O: >35 mg/mL

solubility

H2O: freely soluble, alcohol: freely soluble, chloroform: very slightly soluble, diethyl ether: insoluble

solubility

H2O: >20 mg/mL

solubility

H2O: 15 mg/mL, clear

color

white

color

-

color

white

color

white to beige

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
107H4629V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kieran Rea et al.
Neuropharmacology, 58(7), 962-971 (2010-01-02)
Previous studies suggest that noradrenaline may regulate serotonergic (5-HT) neurotransmission at the serotonin cell body and noradrenaline nerve terminal. Using microdialysis coupled to HPLC, we investigated the effects of alpha1-adrenoceptor manipulation on extracellular serotonin levels - in the ventral hippocampus
J E Wikberg et al.
Journal of neurochemistry, 55(1), 192-203 (1990-07-01)
We have demonstrated previously that [3H]idazoxan, besides being able to bind to alpha 2-adrenergic receptors, may also bind to a nonadrenergic idazoxan-receptor site with high affinity. The idazoxan receptor is tightly bound to cellular membranes, and we have now developed
Miloslav Kolaj et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 292(5), R1907-R1915 (2007-01-16)
The median preoptic nucleus (MnPO) in the lamina terminalis receives a prominent catecholaminergic innervation from the dorsomedial and ventrolateral medulla. The present investigation used whole cell patch-clamp recordings in rat brain slice preparations to evaluate the hypothesis that presynaptic adrenoceptors
View All Related Papers

Global Trade Item Number

SKUGTIN
C223-10MG04061832089690

Questions

Reviews

No rating value

Active Filters