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Antalarmin hydrochloride

Name: Antalarmin hydrochloride
Brand: SIGMA

≥98% (HPLC), solid, CRF1 antagonist

Synonym(s):

N-Butyl-N-ethyl-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolol[2,3-d]pyrimidin-4-amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₄N₄·HCl

CAS Number:

220953-69-5

Molecular Weight:

415.01

UNSPSC Code:

12352200

PubChem Substance ID:

24724401

NACRES:

NA.77

MDL number:

MFCD05664721

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

desiccated

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Properties

Product Name

Antalarmin hydrochloride, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C

InChI

1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H

InChI key

CGDGXEDXEXACKQ-UHFFFAOYSA-N

Description

Application

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Antalarmin hydrochloride has been used:

to study its effect on stress-induced tryptophan hydroxylase 2 activity[1]
to study the anxiogenic effects of corticotropin-releasing factor 1 (CRF1) activation
to analyze the therapeutic effect of blocking corticotrophin-releasing hormone (CRH) signaling in treating social stress-induced depression

Biochem/physiol Actions

Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.

Antalarmin serves as a non steroidal inhibitor of pregnancy even during the early stages. It is known to delay parturition. It also prevents the development of gastric ulcers which arises in response to stress.

Features and Benefits

This compound is featured on the Corticotropin-Releasing Factor Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	T0202	L9167	PZ0100
Sigma-Aldrich A8727 Antalarmin hydrochloride	Sigma-Aldrich T0202 Tocainide hydrochloride	Sigma-Aldrich L9167 LWH-63 hydrochloride	Sigma-Aldrich PZ0100 CP-154526 hydrochloride
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition desiccated	storage condition desiccated, under inert gas	storage condition -	storage condition desiccated
solubility DMSO: >10 mg/mL	solubility DMSO: >20 mg/mL, H₂O: ≥5 mg/mL	solubility DMSO: ~10 mg/mL, H₂O: insoluble	solubility DMSO: 10 mg/mL, clear

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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