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Adenosine, periodate oxidized

Name: Adenosine, periodate oxidized
Brand: SIGMA

≥93%, synthetic, Powder

Synonym(s):

ADOX, Adenosine-2′,3′-dialdehyde

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁N₅O₄

CAS Number:

34240-05-6

Molecular Weight:

265.23

UNSPSC Code:

41106305

PubChem Substance ID:

24891180

NACRES:

NA.51

MDL number:

MFCD00056960

Assay:

≥93%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow

Storage temp.:

−20°C

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Properties

Product Name

Adenosine, periodate oxidized, ≥93%

biological source

synthetic (organic)

Quality Segment

200

assay

≥93%

form

powder

solubility

0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O

InChI

1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)

InChI key

ILMNSCQOSGKTNZ-UHFFFAOYSA-N

Description

Application

Adenosine, periodate oxidized has been used:

as a methylarginine transferase inhibitor in the human embryonic kidney (HEK)-293 T cells[1]
as a methylase inhibitor in H4 neuroglioma[2]
as a broad inhibitor of S-adenosylmethionine (AdoMet)-dependent methyltransferases in mouse embryo fibroblast NIH3T3 cells[3]

Biochem/physiol Actions

Adenosine, periodate oxidized (Adox) is a protein arginine methyltransferases (PRMTs) inhibitor.[4] It also inhibits the enzyme S-adenosylhomocysteine hydrolase and induces apoptosis.[5] Its inhibitory effect on histone methyltransferases prevents histone methylation.[6] Adox also elicits intrinsic cytotoxic properties.[1]

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This Item	A6779	A9376	A6904
Sigma-Aldrich A7154 Adenosine, periodate oxidized	Sigma-Aldrich A6779 Adenosine 5′-triphosphate, periodate oxidized sodium salt	Sigma-Aldrich A9376 Adenosine 2′:3′-cyclic monophosphate sodium salt	Sigma-Aldrich A6904 Adenosine 5′-diphosphate, periodate oxidized sodium salt
biological source synthetic (organic)	biological source bacterial (corynebacterium sp)	biological source synthetic (organic)	biological source -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form powder	form powder	form solid
assay ≥93%	assay ≥97%	assay ≥93%	assay 90-95%
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility 0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow	solubility -	solubility water: 50 mg/mL, clear, colorless	solubility -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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Global Trade Item Number

SKU	GTIN
A7154-25MG	04061833258460
A7154-100MG	04061833258453

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