While stability studies at 37°C have not been conducted, this product ships at ambient temperature and is fairly robust in the powder form. Solutions tend to degrade and lose activity fairly rapidly in the presence of oxygen and at alkaline pH. Additional information is available in the product datasheet available for L-Ascorbic Acid, product A7506:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/221/043/a7506pis.pdf
A4403
L-Ascorbic acid
powder, suitable for cell culture, γ-irradiated
Synonym(s):
L-Threoascorbic acid, Antiscorbutic factor, Vitamin C
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About This Item
Empirical Formula (Hill Notation):
C6H8O6
CAS Number:
Molecular Weight:
176.12
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-066-2
Beilstein/REAXYS Number:
84272
MDL number:
Form:
powder
Pricing and availability is not currently available.
biological source
synthetic (organic)
Quality Segment
sterility
γ-irradiated
form
powder
mol wt
Mw 176.12 g/mol
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable
color
white to off-white
pH
1.0-2.5 (25 °C, 176 g/L in water)
mp
190-194 °C (dec.)
solubility
H2O: 10 mg/mL
SMILES string
OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O
InChI
1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1
InChI key
CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Gene Information
human ... SLC23A2(9962)
General description
L-ascorbic acid is an unsaturated γ-lactone ring containing an enediol configuration (–COH=COH) attached with a carbonyl group.[1]
Application
For use in cell culture applications as an antioxidant and to regenerate tocopherol.
L-ascorbic acid has been used:
L-ascorbic acid has been used:
Biochem/physiol Actions
L-ascorbic acid mainly exhibits antioxidant properties. It protects plants from oxidative stress and mammals from diseases associated with oxidative stress. L-ascorbic acid mainly protects from hydroxyl radicals, superoxide and singlet oxygen. In addition, it also reduces the membrane-linked antioxidant α-tocopherol (oxidised form).[5] L-Ascorbic acid enhances endothelium-dependent vasodilation in various disorders, including diabetes, coronary artery disease, hypertension and chronic heart failure.[1]
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This Item | |||
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form powder | form crystalline | form crystalline | form powder |
| solubility H2O: 10 mg/mL | solubility water: soluble 50 mg/mL | solubility H2O: 0.5 M, clear, colorless | solubility water: soluble 50 mg/mL |
| pH 1.0-2.5 (25 °C, 176 g/L in water) | pH 1.0-2.5 (25 °C, 176 g/L in water) | pH 1.0-2.5 (25 °C, 176 g/L in water) | pH 1.0-2.5 (25 °C, 176 g/L in water) |
| mp 190-194 °C (dec.) | mp 190-194 °C (dec.) | mp 190-194 °C (dec.) | mp 190-194 °C (dec.) |
| technique(s) cell culture | insect: suitable, cell culture | plant: suitable, cell culture | mammalian: suitable | technique(s) HPLC: suitable, cell culture | stem cell: suitable | technique(s) cell culture | mammalian: suitable | technique(s) HPLC: suitable |
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Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Do you happen to have any information on how long L-ascorbic acid remains stable at 37°C? Do you have any idea after how much time the full activity of this compound is lost?
1 answer-
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What is the right storage condition for the powder upon its arrival?
1 answer-
This product may be stored at room temperature in powder form.
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In what solvents is A4403 soluble?
1 answer-
The product A4403 is soluble in water at a concentration of 10 mg/ml, resulting in a clear solution.
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What is the recommended storage method for stock solutions of item A4403, L-Ascorbic acid?
1 answer-
Stock solutions of item A4403, L-Ascorbic acid, can be stored at -20°C for long-term (months to years) stability.
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