![[Arg13] Amyloid-β-Protein Fragment 1-40 ≥80% (HPLC), lyophilized powder](/deepweb/assets/sigmaaldrich/product/images/132/249/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e/640/f6ab5ff8-bec9-4c18-b8b8-7b6bc8f9d58e.jpg)
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A1075
Amyloid β Protein Fragment 1-40
≥90% (HPLC), powder
Synonym(s):
Aβ40
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About This Item
Empirical Formula (Hill Notation):
C194H295N53O58S
CAS Number:
Molecular Weight:
4329.80
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Form:
powder
Assay:
≥90% (HPLC)
Pricing and availability is not currently available.
General description
Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.
Application
Amyloid β Protein Fragment 1-40 has been used:
- in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
- as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma
- as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts[1]
Biochem/physiol Actions
Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.
Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels.
Preparation Note
For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.
Other Notes
Lyophilized from 0.1% TFA in H2O
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥90% (HPLC) | assay ≥95% (HPLC) | assay ≥90% (HPLC) | assay ≥80% (HPLC) |
| form powder | form powder | form powder | form lyophilized powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| solubility 1% acetic acid: 1 mg/mL, saline: insoluble | solubility - | solubility - | solubility H2O: soluble |
| Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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