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62035

Poloxamer 407

oxyethylene 71.5-74.9 %

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F 127

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12352104
NACRES:
NA.25
MDL number:
MFCD00082049
Pricing and availability is not currently available.
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form

powder

Quality Level

100

mol wt

average mol wt 9840 -14600 g/mol (MMMolecular weightMolecular weight
Molecular wei
g)

composition

oxyethylene, 71.5-74.9%

impurities

≤1 ppm ethylene oxide, ≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤0.75% water, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, ≤5 ppm propylene oxide, 50-125 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH3OH

pH

5.0-7.5 (1:40 in H2O)

solubility

10%, clear, colorless

density

1,06 g/cm3 at 25 °C

application(s)

chemicals and industrial polymers

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Application

Poloxamer 407 has been widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 407 grades are poloxamers from the extensive line of Pluronic® block copolymers.

Legal Information

Pluronic is a registered trademark of BASF

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Show Differences

1 of 1

This Item
167581.37112P2164009
Poloxamer 407 oxyethylene 71.5-74.9 %

Sigma-Aldrich

62035

Poloxamer 407

Poloxamer 407 purified, non-ionic

Sigma-Aldrich

16758

Poloxamer 407

Poloxamer 188 EMPROVE® EXPERT, (stabilized with 70ppm BHT), Ph. Eur., ChP, NF

SAFC

1.37112

Poloxamer 188

Poloxamer 188 European Pharmacopoeia (EP) Reference Standard

P2164009

Poloxamer 188

form

powder

form

powder

form

solid

form

-

application(s)

chemicals and industrial polymers

application(s)

-

application(s)

liquid formulation
ophthalmics
parenterals
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation
solubility enhancement

application(s)

pharmaceutical (small molecule)

density

1,06 g/cm3 at 25 °C

density

-

density

1.06 g/cm3 at 25 °C

density

-

solubility

10%, clear, colorless

solubility

soluble, clear, colorless

solubility

-

solubility

-

mol wt

average mol wt 9840 -14600 g/mol (MMMolecular weightMolecular weight
Molecular wei
g)

mol wt

-

mol wt

-

mol wt

-

impurities

≤0.25% ethylene glycol and diethylene glycol, ≤0.75% water, ≤2 ppm arsenic traces, ≤5 ppm dioxan, 50-125 ppm butylhydroxytoluene, ≤0.4% total ash, ≤20 ppm heavy metals, ≤1 ppm ethylene oxide, ≤5 ppm propylene oxide

impurities

≤1.0% water

impurities

-

impurities

-

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4154
BCCP1727
BCCL8133
BCCK9605
BCCH1473

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Tsz Chung Lai et al.
Colloids and surfaces. B, Biointerfaces, 99, 27-37 (2011-10-18)
Polyplex particles formed with plasmid DNA (pDNA) and Pluronic P85-block-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (P85-b-P[Asp(DET)]) demonstrated highly effective transfection ability compared to PEG-based block cationomer, PEG-b-P[Asp(DET)]. Ternary polyplexes comprising PEG-b-P[Asp(DET)], poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-P[Asp(DET)] (P(EPE)-b-P[Asp(DET)]) used as an analog of P85-b-P[Asp(DET)], and pDNA were
Xijun Zhang et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)
This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report
A N Sklifas et al.
Biofizika, 57(2), 317-324 (2012-05-19)
The adsorption abilities of the perfluorocarbon emulsion stabilized by Proxanol 268 were investigated in vitro and in vivo. In vitro, the saturation point for the blood plasma proteins was nearly reached after five minutes of incubation of the emulsion with
View All Related Papers

Global Trade Item Number

SKUGTIN
62035-1KG04061832701141

Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. I plan to dissolve the Poloxamer 407 powder (Sigma, 16758) in sterile distilled water at 4°C overnight and use it as a solution. Could you provide information on the optimal storage temperature and shelf life for the solution form?

    1 answer

    1. There is no information available on the shelf life of Poloxamer 407 in solution. It is typically recommended to store solutions at room temperature.

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. How about the Mw of the product?

    1 answer

    1. The average molecular weight of this product is 10000 to 14600 g/mol.

      Helpful?

  5. is it a pharma grade ?

    1 answer

    1. This product is not pharma grade.

      Helpful?

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