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N,N-Dimethyl-6-propionyl-2-naphthylamine

Name: <I>N,N</I>-Dimethyl-6-propionyl-2-naphthylamine
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥98.0% (HPLC)

Synonym(s):

2-(Dimethylamino)-6-propionylnaphthalene, 6-Propionyl-2-(dimethylamino)naphthalene, Prodan

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₇NO

CAS Number:

70504-01-7

Molecular Weight:

227.30

UNSPSC Code:

12352116

NACRES:

NA.32

PubChem Substance ID:

57650063

MDL number:

MFCD00056615

Beilstein/REAXYS Number:

2723587

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Properties

product line

BioReagent

Quality Level

100

assay

≥98.0% (HPLC)

form

solid

solubility

DMF: soluble, acetone: soluble, acetonitrile: soluble, methanol: soluble

fluorescence

λ_ex 361 nm; λ_em 498 nm in methanol

suitability

suitable for fluorescence

SMILES string

CCC(=O)c1ccc2cc(ccc2c1)N(C)C

InChI

1S/C15H17NO/c1-4-15(17)13-6-5-12-10-14(16(2)3)8-7-11(12)9-13/h5-10H,4H2,1-3H3

InChI key

MPPQGYCZBNURDG-UHFFFAOYSA-N

Description

Application

N,N-Dimethyl-6-propionyl-2-naphthylamine (Prodan), a membrane surface probe, may be used as a fluorescence probe in non-cell based in vitro assay for the determination of drug-phospholipid complex formation and to study membrane surface properties.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Fluorescence of spectrin-bound Prodan[1]

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This Item	40227	05937	14795
Sigma-Aldrich 41525 N,N-Dimethyl-6-propionyl-2-naphthylamine	Sigma-Aldrich 40227 6-Dodecanoyl-N,N-dimethyl-2-naphthylamine	Sigma-Aldrich 05937 N,N-Dimethylallylamine	Sigma-Aldrich 14795 N,N,N′,N′-Tetramethyl-1,8-naphthalenediamine
suitability suitable for fluorescence	suitability suitable for fluorescence	suitability -	suitability -
fluorescence λ_ex 361 nm; λ_em 498 nm in methanol	fluorescence λ_ex 366 nm; λ_em 497 nm in methanol	fluorescence -	fluorescence -
solubility DMF: soluble, acetonitrile: soluble, methanol: soluble, acetone: soluble	solubility DMF: soluble, acetonitrile: soluble, methanol: soluble	solubility -	solubility -
form solid	form -	form -	form solid
assay ≥98.0% (HPLC)	assay ≥97.0% (HPLC)	assay -	assay ≥99.0% (NT)
product line BioReagent	product line -	product line -	product line -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Predicting phospholipidosis: a fluorescence noncell based in vitro assay for the determination of drug-phospholipid complex formation in early drug discovery.

Liping Zhou et al.

Analytical chemistry, 83(18), 6980-6987 (2011-07-28)

This paper describes for the first time, a high-throughput fluorescence noncell based assay to screen for the drug-phospholipid interaction, which correlates to phospholipidosis. Anionic amphiphilic phospholipids can form complexes in aqueous solution, and its critical micelle concentration (CMC) can be

PRODAN-conjugated DNA: synthesis and photochemical properties.

Kazuki Tainaka et al.

Journal of the American Chemical Society, 129(15), 4776-4784 (2007-03-24)

A solvatochromic fluorophore, PRODAN, has been used as a microenvironment-sensitive reporter. Based on the chemistry of PRODAN, we designed and synthesized four novel fluorescent nucleosides, PDNX (X = U, C, A, and G), to which a PRODAN fluorophore was attached

Fluorescence of spectrin-bound prodan.

A Chakrabarti

Biochemical and biophysical research communications, 226(2), 495-497 (1996-09-13)

A large blue-shift (delta lambda max = 87 nm) in the fluorescence emission maximum and 2-fold enhancement in the emission intensity of PRODAN in the presence of 1.5 microM dimeric spectrin from the same aqueous buffer was observed. Binding of

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Global Trade Item Number

SKU	GTIN
41525-100MG	04061832531953
41525-25MG	04061832086330

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