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T0699

Trichloroacetic acid solution

6.1 N

Synonym(s):

TCA

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About This Item

Linear Formula:
Cl3CCOOH
CAS Number:
76-03-9
Molecular Weight:
163.39
UNSPSC Code:
12352106
NACRES:
NA.26
PubChem Substance ID:
57654645
MDL number:
MFCD00004177
Beilstein/REAXYS Number:
970119
Concentration:
6.1 N, ~100 % (w/v)
Form:
liquid
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form

liquid

Quality Level

200

concentration

6.1 N, ~100 % (w/v)

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

General description

Trichloroacetic acid (TCA) is a strong acid. At the pH of drinking water, TCA exists almost in salt form.

Application

Trichloroacetic acid solution has been used:
  • in indoleamine 2,3-dioxygenase (IDO) enzyme assay to hydrolyze N-formylkynurenine and produce kynurenine
  • in the proliferation of human pulmonary artery smooth muscle cells (HPASMCs)
  • to treat ground tissue and precipitate proteins during protein extraction and quantification

Biochem/physiol Actions

Trichloroacetic acid solution is traditionally used to precipitate protein. It can be used to determine protein concentration by quantitative precipitation. Trichloroacetic acid can also be used as a decalcifier and fixative in microscopy.
Trichloroacetic acid (TCA) with no known systemic toxicity, is used as a time-honored agent for superficial peeling. It is a peroxisome proliferator.

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This Item
T91599123091228
Trichloroacetic acid solution 6.1 N

Sigma-Aldrich

T0699

Trichloroacetic acid solution

Trichloroacetic acid BioXtra, ≥99.0%

Sigma-Aldrich

T9159

Trichloroacetic acid

Trichloroacetic acid ACS reagent, for the determination of Fe in blood according to Heilmeyer, ≥99.5%

Sigma-Aldrich

91230

Trichloroacetic acid

Trichloroacetic acid BioUltra, ≥99.5% (T)

Sigma-Aldrich

91228

Trichloroacetic acid

concentration

6.1 N, ~100 % (w/v)

concentration

-

concentration

-

concentration

-

form

liquid

form

-

form

flakes

form

crystals, flakes

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

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signalword

Danger

target_organs

Respiratory system

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1 - STOT SE 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000518211
0000518211
0000474859
0000474859
0000446261

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Guillaume Laflamme et al.
Cell reports, 26(11), 2875-2889 (2019-03-14)
The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or
Alan Mortensen et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 18(1), 55-62 (2012-10-17)
The ratio of the nitric oxide synthase (NOS) cofactor tetrahydrobiopterin (BH(4)) to its oxidized form dihydrobiopterin (BH(2)) has been suggested as an index of endothelial dysfunction. Consequently, much effort has been put into preserving the in vivo equilibrium between these
Valentina Folgiero et al.
Oncotarget, 5(8), 2052-2064 (2014-06-07)
Microenvironmental factors contribute to the immune dysfunction characterizing acute myeloid leukemia (AML). Indoleamine 2,3-dioxygenase 1 (IDO1) is an interferon (IFN)-γ-inducible enzyme that degrades tryptophan into kynurenine, which, in turn, inhibits effector T cells and promotes regulatory T-cell (Treg) differentiation. It
View All Related Papers

Global Trade Item Number

SKUGTIN
T0699-100ML04061837335778

Questions

1–4 of 4 Questions  

  1. Where can I find the IFU for this reagent please?

    1 answer

    1. Instructions for Use are not included with this product. The material is intended for research use in general laboratory applications. However, there are several application-based resources available at the links below.

      Protein Precipitation
      https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/protein-biology/protein-lysis-and-extraction/precipitation-procedures

      Enzymatic Activity of Glucose-6-Phosphatase
      https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/enzyme-activity-assays/enzymatic-assay-of-glucose-6-phosphatase

      Enzymatic Assay of Ficin
      https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/enzyme-activity-assays/enzymatic-assay-of-ficin

      Enzymatic Assay of Amyloglucosidase
      https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/enzyme-activity-assays/enzymatic-assay-of-amyloglucosidase

      Helpful?

  2. Is solution prepared in water at 1g/ml concentration?

    1 answer

    1. This product is prepared in water at approximately 1.0 g/mL. The concentration may range from 5.8 - 6.1M or 0.947 - 1.05 g/mL. The lot-specific molarity of this solution is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot-specific Certficate:
      https://www.sigmaaldrich.com/product/sigma/t0699#product-documentation

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  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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