The storage stability of this product at -80°C has not been tested, and stability depends on factors such as solvent composition, freeze-thaw cycles, and storage conditions. Typical stock solutions can be prepared at concentrations of 50–500 mg solid (powder) in 1 ml water. Solutions should be stored in working aliquots at -20°C. This product can be stored in working aliquots in tightly sealed containers at -20°C for 6 months. Avoid repeated freeze-thaw cycles. More information can be found in the document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/218/859/e8014inf.pdf
P7556
Progesterone-Water Soluble
powder, BioReagent, suitable for cell culture
Synonym(s):
Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex
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About This Item
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥65% (HPLC)
Pricing and availability is not currently available.
biological source
synthetic (organic)
Quality Segment
product line
BioReagent
assay
≥65% (HPLC)
form
powder
concentration
≥65% (HPLC)
technique(s)
cell culture | mammalian: suitable
solubility
H2O: 25 mg/mL, clear to slightly hazy
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
InChI
1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChI key
RJKFOVLPORLFTN-LEKSSAKUSA-N
Gene Information
human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)
General description
Progesterone is a steroid hormone secreted by the ovaries.
Application
This product is not recommended for use in binding assays.
Progesterone-Water Soluble has been used:
- for in vitro maturation of oocyte complexes
- as a σ1R antagonist to study its effect on sigma 1 receptor
- to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro
Biochem/physiol Actions
Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.
Packaging
Package size based on progesterone content
Other Notes
Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.
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This Item | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) | biological source synthetic (organic) |
| assay ≥65% (HPLC) | assay ≥99% | assay ≥99% | assay - |
| product line BioReagent | product line BioReagent | product line BioXtra | product line BioReagent |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| form powder | form powder | form powder | form powder |
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Lact. - Repr. 1A
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| P7556-100MG | 04061834395355 |
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What is the storage stability of aliquots [1mM] at -80°C?
1 answer-
Helpful?
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What is the molecular weight (MW) of progesterone? How should I account for the fact that the compound contains approximately 70 mg of progesterone per gram, with the remainder being methyl-β-cyclodextrin? How many milligrams of this mixture do I need
1 answer-
The molecular weight for the compound progesterone is 314.46 g/mole. When calculating molar (e.g., :M, mM, etc.) solutions, the molecular weight of
the cyclodextrin component of the complex is typically disregarded, and the solution is prepared considering the amount of the hormone in the preparation and its respective molecular weight. The lot specific certificate of analysis can be reviewed to determine the mg of progesterone present in the solid. This value can then be converted to a mole value with the molecular weight and the solution volume being adjusted to reach the desired concentration.Helpful?
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How long can it be stored as 1mM solution at -20?
1 answer-
Progesterone-Water Soluble (P7556) can be stored in aliquots at -20 C for 6 months. Avoid repeated freeze thaws.
Helpful?
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