Key Documents

KN-62

Name: KN-62
Brand: SIGMA

≥95%, powder

Synonym(s):

(S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine

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About This Item

Empirical Formula (Hill Notation):

C₃₈H₃₅N₅O₆S₂

CAS Number:

127191-97-3

Molecular Weight:

721.84

NACRES:

NA.77

PubChem Substance ID:

24895961

UNSPSC Code:

12352200

MDL number:

MFCD00083180

Assay:

≥95%

Form:

powder

Pricing and availability is not currently available.

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Properties

biological source

synthetic (organic)

Quality Segment

200

assay

≥95%

form

powder

color

yellow

mp

130 °C

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL, methanol: 10 mg/mL, DMSO: 12 mg/mL, chloroform: 20 mg/mL

storage temp.

−20°C

SMILES string

O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O

InChI

1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

InChI key

RJVLFQBBRSMWHX-DHUJRADRSA-N

Gene Information

human ... P2RX7(5027)

Description

Biochem/physiol Actions

Selectively inhibits rat brain Ca²⁺/calmodulin-dependent protein kinase II.

Features and Benefits

This compound is featured on the Ca/CaMKs and P2 Receptors: P2X Ion Channel Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Show Differences

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This Item	SML2384	S8010	N2790
Sigma-Aldrich I2142 KN-62	Sigma-Aldrich SML2384 BAY 87-2243	Sigma-Aldrich S8010 (±)-Sulpiride	Sigma-Aldrich N2790 Nucleozin
assay ≥95%	assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 200	Quality Level -	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL, DMSO: 12 mg/mL, methanol: 10 mg/mL, chloroform: 20 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL, 0.1 M HCl: soluble, H₂O: slightly soluble, ethanol: soluble	solubility DMSO: >15 mg/mL
color yellow	color white to beige	color white	color yellow

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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