E2375

Emetine dihydrochloride

RNA polymerase inhibitor

• Synonym(s): 6′,7′,10,11-Tetramethoxyemetan dihydrochloride
• Empirical Formula (Hill Notation): C₂₉H₄₀N₂O₄ · 2HCl
• CAS Number: 316-42-7
• Molecular Weight: 553.56
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278410
• NACRES: NA.77
• MDL number: MFCD00242944

Properties

• Product Name: Emetine dihydrochloride,
• Quality Segment: 100
• antibiotic activity spectrum: parasites
• mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12C[C@H](C[C@@]3([H])NCCC4=C3C=C(OC)C(OC)=C4)[C@@H](CC)CN1CCC5=C2C=C(OC)C(OC)=C5
• InChI: 1S/C29H40N2O4.2ClH/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H/t18-,21-,24+,25-;;/m0../s1
• InChI key: JROGBPMEKVAPEH-GXGBFOEMSA-N

Description

Application

Emetine dihydrochloride has been used:

• as a protein synthesis inhibitor to study its effects on human papillomavirus type 8 E2 protein half-life[1]
• to study its effects on the stress granules assembly[2]
• as a chain-elongation inhibitor in puromycin assay for protein synthesis[3]

Biochem/physiol Actions

Emetine dihydrochloride is a member of the ipecac alkaloids family. It can mediate inhibition of protein and nucleic acid synthesis. It exhibits antiviral activity against dengue virus infection and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).[4] Emetine dihydrochloride exhibits anti-proliferative effects against bladder cancer cells.[5] It also possesses anti-protozoal activity.[4]

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300,H315,H319
• pcodes: P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 1 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable