This product is not sterile. Prepared solutions may be filter sterilized.
D0627
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
≥96% (HPLC), synthetic (organic), powder
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt
Synonym(s):
Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt
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About This Item
Linear Formula:
C18H23N5O8PNa
CAS Number:
Molecular Weight:
491.37
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
241-059-4
MDL number:
Assay:
≥96% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
H2O: 100 mg/mL
Storage temp.:
−20°C
Pricing and availability is not currently available.
Product Name
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt, ≥96% (HPLC), powder
biological source
synthetic (organic)
Quality Level
assay
≥96% (HPLC)
form
powder
impurities
≤0.5% Cyclic AMP, ≤3% monobutyryl derivatives
color
off-white
solubility
H2O: 100 mg/mL
storage temp.
−20°C
SMILES string
[Na+].CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3OC(=O)CCC
InChI
1S/C18H24N5O8P.Na/c1-3-5-11(24)22-16-13-17(20-8-19-16)23(9-21-13)18-15(30-12(25)6-4-2)14-10(29-18)7-28-32(26,27)31-14;/h8-10,14-15,18H,3-7H2,1-2H3,(H,26,27)(H,19,20,22,24);/q;+1/p-1/t10-,14-,15-,18-;/m1./s1
InChI key
KRBZRVBLIUDQNG-JBVYASIDSA-M
Application
Dibutyryl CAMP is a cell-permeable CAMP analogue that activates CAMP dependent protein kinase (PKA) or the CAMP/PKA signaling pathway. Dibutyryl CAMP is used as a morphological differentiation inducer and cell signaling modulator in cells such as Schwann cells. Dibutyrl cAMP is used in a variety of differentiation studies, such as neuron differentiation / neuronal differentiation.
Biochem/physiol Actions
Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
Disclaimer
Loses 2′-O-butyryl group at pH 8.5
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This Item | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source - | biological source synthetic | biological source synthetic (organic) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| assay ≥96% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) | assay ≥93% |
| form powder | form powder | form powder | form powder |
| color off-white | color white | color - | color - |
| solubility H2O: 100 mg/mL | solubility H2O: 100 mg/mL | solubility water: 50 mg/mL, clear, colorless | solubility water: 50 mg/mL, clear, colorless |
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| D0627-100MG | 04061833557877 |
| D0627-1G | 04061833557884 |
| D0627-5X1G | 04061833557914 |
| D0627-250MG | 04061833557891 |
| D0627-25MG | 04061833557907 |
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is this product sterile?
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How long is it stable in -20ºC after reconstitution in DMSO or H2O at 200mM? Do you have any recommendations for stability once the product is in solution?
1 answer-
This product is soluble in water at 100 mg/mL. The solubility in DMSO has not been determined. Following reconstitution, aliquot and freeze at -20°C for up to 3 months or refrigerate at 2 - 8°C for up to 3 days. Avoid pH of 8.5 or greater as hydrolysis will occur. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/368/353/d0627pis-ms.pdfHelpful?
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