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A2202

ω-Agatoxin TK

~98% (HPLC), powder

Synonym(s):

ω-Aga-TK

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About This Item

Empirical Formula (Hill Notation):
C215H337N65O70S10
CAS Number:
158484-42-5
Molecular Weight:
5273.02
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00286234
Form:
powder
Assay:
~98% (HPLC)
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assay

~98% (HPLC)

Quality Level

200

form

powder

solubility

H2O: soluble (Aqueous stock solution is stable for 1 month at 2-8 °C and for several months at -20 °C.)

storage temp.

−20°C

Gene Information

human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)

Biochem/physiol Actions

Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective P-type and Q-type calcium-channel blocker, without effect on L-type, N-type, or T-type calcium channels. Used to differentiate the types of calcium channel active during various physiological processes

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This Item
M8278K1514T4376
ω-Agatoxin TK ~98% (HPLC), powder

Sigma-Aldrich

A2202

ω-Agatoxin TK

Margatoxin

Sigma-Aldrich

M8278

Margatoxin

Kurtoxin

Sigma-Aldrich

K1514

Kurtoxin

N-p-Tosyl-L-phenylalanine chloromethyl ketone ≥97% (TLC), powder

Sigma-Aldrich

T4376

N-p-Tosyl-L-phenylalanine chloromethyl ketone

assay

~98% (HPLC)

assay

-

assay

-

assay

≥97% (TLC)

form

powder

form

powder

form

solid

form

powder

solubility

H2O: soluble (Aqueous stock solution is stable for 1 month at 2-8 °C and for several months at -20 °C.)

solubility

-

solubility

-

solubility

DMSO: >10 mg/mL (stable for several months at 4°C.), ethanol: 20 mg/mL

Gene Information

human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)

Gene Information

human ... CACNA1D(776)
mouse ... CACNA1D(12289)
rat ... CACNA1D(29716)

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)
mouse ... CACNA1G(12291), CACNA1H(58226), CACNA1I(239556)
rat ... CACNA1G(29717), CACNA1H(114862), CACNA1I(56827)

Gene Information

human ... NFKB1(4790), NKAP(79576), NKRF(55922), NOS2(4843), PTGS2(5743)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
110M1501
127K1082
036K1334
128H0772
101K1417

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Y Q Lin et al.
Journal of the autonomic nervous system, 73(1), 26-37 (1998-11-10)
The sympathetic preganglionic nerve terminals of the rat superior cervical ganglion were loaded with the calcium indicator oregon green 488 BAPTA-1 to measure the change in calcium concentration in the terminal boutons, (delta[Ca2+]b) following short (1 or 5 impulses) and
Q Q Sun et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(18), 6839-6849 (1997-09-15)
The primary sensory Rohon-Beard (R-B) neurons of Xenopus larvae are highly analogous to the C fibers of the mammalian pain pathway. We explored the actions of 5-HT by studying the modulation of Ca2+ currents. In approximately 80% of the acutely
T Teramoto et al.
Biochemical and biophysical research communications, 196(1), 134-140 (1993-10-15)
In the course of purification of omega-Aga-IVA, a specific P-type calcium channel blocker, from the venom of Agelenopsis aperta we discovered a novel peptide. This peptide, named omega-agatoxin Tsukuba (omega-Aga-TK), also blocked P-type channels and was twelve times more abundant
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Global Trade Item Number

SKUGTIN
A2202-.1MG04061833627006

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