Key Documents

(±)-Sodium β-hydroxyisobutyrate

Name: (±)-Sodium β-hydroxyisobutyrate
Brand: SIGMA

≥96.0%

Synonym(s):

β-Hydroxyisobutyric acid sodium salt, (±)-β-HIBA-Na, 3-Hydroxy-2-methylpropionic acid sodium salt, Sodium 3-hydroxy-2-methylpropionate

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About This Item

Empirical Formula (Hill Notation):

C₄H₇NaO₃

CAS Number:

1219589-99-7

Molecular Weight:

126.09

NACRES:

NA.25

PubChem Substance ID:

329755270

UNSPSC Code:

12352106

MDL number:

MFCD16875405

Assay:

≥96.0% (GC), ≥96.0%

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥96.0% (GC), ≥96.0%

form

powder

composition

sodium, 17.5-19.0%

storage temp.

2-8°C

SMILES string

[Na+].CC(CO)C([O-])=O

InChI

1S/C4H8O3.Na/c1-3(2-5)4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1

InChI key

RBJZIQZDAZLXEK-UHFFFAOYSA-M

Description

Application

3-Hydroxyisobutyrate (HIBA) may be used to study the distribution, characterization and kinetics of enzymes involved in branched chain amino acid metabolism such as 3-hydroxyisobutyrate dehydrogenase (EC: 1.1.1.31) and 3-hydroxyisobutyryl-CoA hydrolase (EC: 3.1.2.4).

Biochem/physiol Actions

3-Hydroxyisobutyrate (HIBA), is formed in the valine catabolism[1], it is a reactant of enzyme 3-hydroxyisobutyrate dehydrogenase (EC: 1.1.1.31) and 3-hydroxyisobutyryl-CoA hydrolase (EC: 3.1.2.4); it was found to have increased concentrations in MS patient metabolic profiles[2].

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item	16842	38153	90374
Sigma-Aldrich 36105 (±)-Sodium β-hydroxyisobutyrate	Sigma-Aldrich 16842 Sodium (S)-β-hydroxyisobutyrate	Sigma-Aldrich 38153 8-Hydroxyquinoline-β-D-glucuronide sodium salt	Sigma-Aldrich 90374 Sodium mercaptopyruvate dihydrate
assay ≥96.0% (GC)	assay ≥96.0% (GC)	assay ≥98.0% (HPLC)	assay 97.0-103.0% (NT)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
composition sodium, 17.5-19.0%	composition sodium, 17.5-19.0%	composition -	composition sulfur content, 17.5-18.5%
form powder	form -	form powder	form solid

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Mammalian 3-hydroxyisobutyrate dehydrogenase.

J W Hawes et al.

Methods in enzymology, 324, 218-228 (2000-09-16)

Disorders of the metabolism of amino acids and related compounds.

Shih, V. E. and Mandell, R. et al.

Genetic Disorders and the Fetus, 514-553 (2010)

A branched-chain organic acid linked to multiple sclerosis: first identification by NMR spectroscopy of CSF.

Norbert W Lutz et al.

Biochemical and biophysical research communications, 354(1), 160-164 (2007-01-16)

(1)H NMR spectroscopy of cerebrospinal fluid (CSF) is currently being used to study metabolic profiles characteristic of distinct multiple sclerosis (MS) manifestations. For select MS patient groups, we have previously detected significantly increased concentrations of several identified metabolites and one

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Global Trade Item Number

SKU	GTIN
36105-250MG	04061832404189
36105-1G	04061831824025

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