No, this product has been tested for in vivo application. Unless otherwise stated, this product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals.
30450
Daunorubicin hydrochloride
≥90% (HPLC)
Synonym(s):
Daunomycin hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C27H29NO10 · HCl
CAS Number:
Molecular Weight:
563.98
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
245-723-4
Beilstein/REAXYS Number:
4229221
MDL number:
Pricing and availability is not currently available.
biological source
synthetic
Quality Segment
assay
≥90% (HPLC)
form
powder
color
red to deep red
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
InChI
1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1
InChI key
GUGHGUXZJWAIAS-QQYBVWGSSA-N
Gene Information
human ... TOP2A(7153)
General description
Chemical structure: aminoglycoside
Application
Biochem/physiol Actions
On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
Potent anticancer agent. Inhibits DNA and RNA synthesis as sequence specific ds-DNA intercalating agent.
Packaging
5 mg, 25 mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.
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This Item | |||
|---|---|---|---|
| antibiotic activity spectrum neoplastics | antibiotic activity spectrum - | antibiotic activity spectrum neoplastics | antibiotic activity spectrum - |
| mode of action DNA synthesis | interferes | mode of action - | mode of action DNA synthesis | interferes | mode of action - |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level - |
| form powder | form - | form solid | form - |
| assay ≥90% (HPLC) | assay - | assay - | assay - |
| biological source synthetic | biological source - | biological source - | biological source - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Hi, I'm writing to ask if this product has been pharmacologically tested for in vivo experiments?\thanks !
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