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33429
Doxycycline hyclate
VETRANAL®, analytical standard
Synonym(s):
Doxycycline hydrochloride hemiethanolate hemihydrate
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About This Item
Empirical Formula (Hill Notation):
C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
CAS Number:
Molecular Weight:
512.94
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5702728
Pricing and availability is not currently available.
grade
analytical standard
Quality Segment
agency
EPA 1694
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
solubility
DMSO: soluble 100 mM
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites
application(s)
clinical testing
format
neat
mode of action
protein synthesis | interferes
SMILES string
Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58
InChI
1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1
InChI key
HALQELOKLVRWRI-ZVACAFRPSA-N
General description
Chemical structure: tetracycline
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Mode of Action: Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi.
Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.
Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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This Item | |||
|---|---|---|---|
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - |
| application(s) clinical testing | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) | application(s) pharmaceutical (small molecule) |
| format neat | format neat | format neat | format neat |
| Quality Level 100 | Quality Level 300 | Quality Level - | Quality Level - |
| grade analytical standard | grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
| shelf life limited shelf life, expiry date on the label | shelf life - | shelf life - | shelf life - |
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signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Erdinc Turk et al.
Animals : an open access journal from MDPI, 10(6) (2020-07-01)
The aims of this study in goats were to determine the pharmacokinetics of doxycycline hyclate following single intravenous (IV), intramuscular (IM) and oral administrations of 20 mg/kg and to evaluate the pharmacokinetics and accumulation of doxycycline hyclate after repeated oral
Hanumara Ram Chowdri et al.
Annals of internal medicine, 159(1), 21-27 (2013-07-03)
The diverse tickborne infections of the northeastern United States can present as undifferentiated flu-like illnesses. In areas endemic for Lyme and other tickborne diseases, patients presenting with acute febrile illness with myalgia, headache, neutropenia, thrombocytopenia, and elevated hepatic aminotransferase levels
C Arnoud Meijer et al.
Annals of internal medicine, 159(12), 815-823 (2014-02-04)
Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans. To test whether doxycycline inhibits AAA progression in humans. Randomized, placebo-controlled, double-blind
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 33429-100MG-R | 04061835511433 |
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What is the Department of Transportation shipping information for this product?
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Is doxycycline hyclate soluble in DMSO?
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According to literature sources, doxycycline hyclate is soluble in DMSO at a concentration of 100 mM.
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