One "NIH" unit of thrombin is equivalent to 1.1 to 1.3 International Units, depending on the influence of polyethylene glycol in the assay (Thromb Haemost. 1995 Sep;74(3):900-3). A unitage ratio of 1.15 is recommended based on data obtained in the presence and absence of polyethylene glycol in comparative assays.
Wszystkie zdjęcia(1)
Kluczowe dokumenty
T8885
Thrombin from human plasma
lyophilized powder, Suitable for routine use in the thrombin time test
Synonim(y):
Factor IIa
Zaloguj sięWyświetlanie cen organizacyjnych i kontraktowych
Wybierz wielkość
10 VIALS
975,00 zł
25 VIALS
2060,00 zł
Wybierz wielkość
Zmień widok
10 VIALS
975,00 zł
25 VIALS
2060,00 zł
About This Item
Polecane produkty
pochodzenie biologiczne
human plasma
Poziom jakości
Formularz
lyophilized powder
opakowanie
vial of ≥10 NIH units
zanieczyszczenia
HIV, hepatitis B and hepatitis C, tested negative
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... F2(2147)
Szukasz podobnych produktów? Odwiedź Przewodnik dotyczący porównywania produktów
Opis ogólny
Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects.
Zastosowanie
Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study that compared efficacy and safety of low-molecular-weight heparins (LMWHs) to other anticoagulants as venous thromboembolism prophylaxis in major orthopedic surgery. [1]
Działania biochem./fizjol.
Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.
Definicja jednostki
Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard
Rekonstytucja
When reconstituted with 1 ml H2O, one vial will contain 10 mg bovine serum albumin, 0.15 M NaCl and 0.05 M sodium citrate, pH 6.5
Komentarz do analizy
The NIH assay procedure uses 0.2 ml diluted plasma (1:1 with saline) as a substrate and 0.1ml of thrombin sample (stabilized in a 1% buffered albumin solution) based on a modification of the method of Biggs. Only clotting times in the range of 15-25 seconds are used for determining thrombin concentrations.
Inne uwagi
View more information on thrombin at www.sigma-aldrich.com/enzymeexplorer.
Oświadczenie o zrzeczeniu się odpowiedzialności
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Ta strona może zawierać tekst przetłumaczony maszynowo.
Inhibitor
Numer produktu
Opis
Cennik
Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
Organy docelowe
Respiratory system
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Wybierz jedną z najnowszych wersji:
Certyfikaty analizy (CoA)
Lot/Batch Number
Nie widzisz odpowiedniej wersji?
Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.
Masz już ten produkt?
Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Klienci oglądali również te produkty
Shenghui Huang et al.
Reproductive sciences (Thousand Oaks, Calif.), 29(4), 1170-1187 (2022-02-01)
The development of more efficacious, non-hormonal therapeutics for endometriosis is still an unmet medical need begging to be fulfilled. Growing evidence indicates that endometriotic lesions are wounds undergoing repeated tissue injury and repair, and, as such, platelets play an important
Meihua Hao et al.
Reproductive biology and endocrinology : RB&E, 20(1), 85-85 (2022-06-07)
Women with endometriosis have been shown to have a reduced vagal tone as compared with controls and vagotomy promoted while vagus nerve stimulation (VNS) decelerated the progression of endometriosis in mice. Extensive research also has shown that the activation of
Nathalie Busschaert et al.
Chembiochem : a European journal of chemical biology, 23(6), e202100670-e202100670 (2022-01-06)
The thrombin binding aptamer (TBA) is a 15-mer DNA oligonucleotide (5'-GGT TGG TGT GGT TGG-3'), that can form a stable intramolecular antiparallel chair-like G-quadruplex structure. This aptamer shows anticoagulant properties by interacting with one of the two anion binding sites
Diana M Sobieraj et al.
Pharmacotherapy, 32(9), 799-808 (2012-06-30)
To evaluate the comparative efficacy and safety of low-molecular-weight heparins (LMWHs) versus other anticoagulants as venous thromboembolism prophylaxis in major orthopedic surgery. Systematic review with meta-analysis of 37 randomized controlled trials. Patients undergoing total hip replacement, total knee replacement, or
Antonella Virgilio et al.
Chembiochem : a European journal of chemical biology, 15(16), 2427-2434 (2014-09-13)
We report an investigation into analogues of the thrombin binding aptamer (TBA). Individual thymidines were replaced by the unusual residue 5-hydroxymethyl-2'-deoxyuridine (hmU). This differs from the canonical thymidine by a hydroxyl group on the 5-methyl group. NMR and CD data
-
What is the equivalence in UI of 1 NIH of trombine
1 answer-
Helpful?
-
Active Filters
Nasz zespół naukowców ma doświadczenie we wszystkich obszarach badań, w tym w naukach przyrodniczych, materiałoznawstwie, syntezie chemicznej, chromatografii, analityce i wielu innych dziedzinach.
Skontaktuj się z zespołem ds. pomocy technicznej
