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C9026

Sigma-Aldrich

Caerulein

≥95% (HPLC), suitable for immunohistochemistry

Synonim(y):

Caerulein Sulfated, Cerulein, Ceruletide, [Tyr(SO3H)4]Caerulein, pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

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0.1 MG
954,00 zł
0.5 MG
2190,00 zł
1 MG
3030,00 zł

954,00 zł

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Wszystkie zdjęcia(1)

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Zmień widok
0.1 MG
954,00 zł
0.5 MG
2190,00 zł
1 MG
3030,00 zł

About This Item

Wzór empiryczny (zapis Hilla):
C58H73N13O21S2
Numer CAS:
17650-98-5
Masa cząsteczkowa:
1352.40
Beilstein:
5422487
Numer MDL:
MFCD00076478
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
24893129
NACRES:
NA.26

954,00 zł

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Nazwa produktu

Caerulein, ≥95% (HPLC)

Poziom jakości

200

Próba

≥95% (HPLC)

Formularz

powder

metody

immunohistochemistry: suitable

kolor

white

temp. przechowywania

−20°C

ciąg SMILES

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)C(NC(=O)[C@H](Cc3ccc(OS(O)(=O)=O)cc3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]4CCC(=O)N4)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc5ccccc5)C(N)=O

InChI

1S/C58H73N13O21S2/c1-29(72)49(71-57(87)40(23-31-12-14-33(15-13-31)92-94(89,90)91)68-56(86)43(26-48(78)79)69-52(82)37(16-18-44(59)73)65-51(81)36-17-19-45(74)63-36)58(88)62-28-46(75)64-41(24-32-27-61-35-11-7-6-10-34(32)35)54(84)66-38(20-21-93-2)53(83)70-42(25-47(76)77)55(85)67-39(50(60)80)22-30-8-4-3-5-9-30/h3-15,27,29,36-43,49,61,72H,16-26,28H2,1-2H3,(H2,59,73)(H2,60,80)(H,62,88)(H,63,74)(H,64,75)(H,65,81)(H,66,84)(H,67,85)(H,68,86)(H,69,82)(H,70,83)(H,71,87)(H,76,77)(H,78,79)(H,89,90,91)/t29-,36+,37+,38+,39+,40+,41+,42+,43+,49?/m1/s1

Klucz InChI

YRALAIOMGQZKOW-HJMGKOKZSA-N

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Amino Acid Sequence

Glp-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Zastosowanie

Caerulein has been used to induce pancreatitis in Sprague-Dawley rats, mice and other experimental animals.[1][2][3]

Działania biochem./fizjol.

Caerulein is a gastro regulatory molecule with actions similar to cholecystokinin.[4] It possesses a tyrosine sulfate residue and induces smooth muscle contraction. It has gastrin-like activity.[5] Caerulein is used to study cell signaling mediated by NF-κB upregulation of proteins such as intercellular adhesion molecule-1(ICAM-1) and inflammation related molecules, such as NADPH oxidase and Janus kinase signal transducer.[6] Caerulein also regulates thermoregulation, sedation and satiety.[5]
Effects on perception of pain are conflicting. It prevents gall bladder pain, renal colic, and the pain of intermittent claudication; however, in general, it is seen as an antagonist of endogenous opioids.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
0000405291
0000405293
0000405293
0000405291
0000392996

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia
Gastroenterology, 999-1010 (2016)
Shan-Ming Chen et al.
Scientific reports, 10(1), 20319-20319 (2020-11-25)
Pancreatic cancer is one of the most lethal and chemo-resistant cancers worldwide. Growing evidence supports the theory that the gut microbiota plays an essential role in modulating the host response to anti-cancer therapy. The present study aimed to explore the
Abba Kastin, Abba J. Kastin
Handbook of Biologically Active Peptides (2011)
Membrane Proteome Analysis of Cerulein-Stimulated Pancreatic Acinar Cells: Implication for Early Event of Acute Pancreatitis
Jangwon Lee
Gut and Liver, 4(1) (2010)
Acinar cell apoptosis and the origin of tubular complexes in caerulein-induced pancreatitis
Lynne E Reid
International Journal of Experimental Pathology (1999)
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Questions

1–5 of 5 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How do I store solutions of Product C9026, Caerulein?

    1 answer

    1. Solutions can be frozen at pH>7 for a least a week, and may be good for several months.

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  4. What is Product C9026, Caerulein, soluble in?

    1 answer

    1. It is soluble in 50 mM ammonium hydroxide at a concentration of 1 mg/mL. Note that this is information from analytical testing, and is not application based.

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  5. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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