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Dokumenty

P1061

Supelco

Proadifen hydrochloride

analytical standard, ≥95%

Synonim(y):

α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester, N,N-Diethylaminoethyl 2,2-diphenylvalerate, SKF-525A

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About This Item

Wzór empiryczny (zapis Hilla):
C23H31NO2 · HCl
Numer CAS:
62-68-0
Masa cząsteczkowa:
389.96
Numer MDL:
MFCD00055151
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329820069
NACRES:
NA.24

klasa czystości

analytical standard

Poziom jakości

200

Próba

≥95%

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

122-123 °C

Zastosowanie

forensics and toxicology
pharmaceutical (small molecule)

format

neat

temp. przechowywania

−20°C

ciąg SMILES

Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2

InChI

1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H

Klucz InChI

FHIKZROVIDCMJA-UHFFFAOYSA-N

informacje o genach

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

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Zastosowanie

Proadifen hydrochloride may be used as an internal standard in the determination of analgesic agents like O-desmethyltramadol, tramadol and N-desmethyltramadol in human urine samples using gas chromatography coupled with mass spectrometry (GC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Działania biochem./fizjol.

Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase and cytochrome P450
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certyfikaty analizy (CoA)

Lot/Batch Number
0000346067
0000346068
0000285385
0000263883
SLCN9419

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Supelco

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Sigma-Aldrich

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Trizma® base

Resorufin 95%

Sigma-Aldrich

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Resorufin

L-Threonine reagent grade, ≥98% (HPLC)

Sigma-Aldrich

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Sigma-Aldrich

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HEPES ≥99.5% (titration)

Sigma-Aldrich

H3375

HEPES

David Fuchs et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(4), 158611-158611 (2020-01-10)
Trihydroxyoctadecenoic acids (TriHOMEs) are linoleic acid-derived lipid mediators reported to be dysregulated in obstructive lung disease. In contrast to many other oxylipins, TriHOME biosynthesis in humans is still poorly understood. The association of TriHOMEs with inflammation prompted the current investigation
Amber Woodard et al.
AIMS neuroscience, 6(1), 25-42 (2020-04-29)
Neuronal nitric oxide (nNO) has been shown to affect motor function in the brain. Specifically, nNO acts in part through regulation of dopamine (DA) release, transporter function, and the elicitation of neuroprotection/neurodegeneration of neurons in conditions such as Parkinson's disease
Simultaneous determination of tramadol, O-desmethyltramadol and N-desmethyltramadol in human urine by gas chromatography?mass spectrometry
El-Sayed Y A-A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 926, 9-15 (2013)
Joseph A Crifasi et al.
Journal of analytical toxicology, 30(8), 581-592 (2006-11-30)
Stir bar sorptive extraction is an innovative sample extraction technique that can be used to process blood, urine, and tissue samples for routine drug screening in the forensic toxicology laboratory. The Gerstel Twister desorption unit (TDU) system is a multifunctional
Daniele Giovanni Ghiglioni et al.
Pharmaceutics, 12(4) (2020-04-25)
In this study, a sensitive quantitative method based on high performance liquid chromatography combined with high-resolution mass spectrometry, Q ExactiveTM-Orbitrap® was set up and applied for the determination of the immunosuppressor agents cyclosporine A and tacrolimus in novel ethanol-free ophthalmic
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