G1251

L-Glutamic acid

≥99% (HPLC), suitable for microbiological culture, ReagentPlus^®

• Synonim(y): (S)-2-Aminopentanedioic acid, Glu
• Wzór liniowy: HO₂CCH₂CH₂CH(NH₂)CO₂H
• Numer CAS: 56-86-0
• Masa cząsteczkowa: 147.13
• NACRES: NA.26
• PubChem Substance ID: 24895052
• eCl@ss: 32160406
• UNSPSC Code: 12352209
• EC Number: 200-293-7
• MDL number: MFCD00002634
• Beilstein/REAXYS Number: 1723801

Właściwości

• Nazwa produktu: L-Glutamic acid, ReagentPlus^®, ≥99% (HPLC)
• agency: suitable for SM 5210
• Quality Segment: 200
• product line: ReagentPlus^®
• assay: ≥99% (HPLC)
• form: powder
• technique(s): microbiological culture: suitable
• color: white to off-white
• mp: 205 °C (dec.) (lit.)
• solubility: 1 M HCl: soluble 100 mg/mL
• density: 1.54 g/cm³ at 20 °C
• cation traces: C: 40.4-41.2%, N: 9.2-9.8%
• SMILES string: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• InChI key: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Gene Information: human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506) ; rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482) ;

Opis

Application

L-Glutamic acid has been used to enhance endogenous acetylcholine overflow. It has been used as a supplement in the growth medium of meat-Spoiling Pseudomonas fragi 72.

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase.
Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• PPE (środki ochrony indywidualnej): Eyeshields, Gloves, type N95 (US)